Evidence map›Paper›PMID 26189060›Full record

ArticleBrain imaging and behavior2016

Test-retest reliability of high angular resolution diffusion imaging acquisition within medial temporal lobe connections assessed via tract based spatial statistics, probabilistic tractography and a novel graph theory metric.

T Kuhn, J M Gullett, P Nguyen, A E Boutzoukas, A Ford, L M Colon-Perez, W Triplett, P R Carney, T H Mareci, C C Price and 1 more

Abstract read
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In one paragraph

Article in Brain imaging and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

T KuhnDepartment of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL, 32610, USA. tkuhn@phhp.ufl.edu.
J M GullettDepartment of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL, 32610, USA.
P NguyenDepartment of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL, 32610, USA.
A E BoutzoukasDepartment of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL, 32610, USA.
A FordDepartment of Neuroscience, University of Florida, Gainesville, FL, USA.
L M Colon-PerezDepartment of Physics, University of Florida, Gainesville, FL, USA.
W TriplettDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
P R CarneyDepartment of Pediatrics, University of Florida, Gainesville, FL, USA.
T H MareciDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, USA.
C C PriceDepartment of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL, 32610, USA.
R M BauerDepartment of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL, 32610, USA.

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
White Matter Connectivity and PD Cognitive PhenotypesR01NS082386 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2013 to 2017
$2.3M
Neuroimaging Biomarkers for Post-Operative Cognitive Decline in Older AdultsR01NR014181 · NINR · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2012 to 2016
$2.3M
White Matter and Cognition in Parkinson's DiseaseK23NS060660 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2007 to 2011
$619k
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001427NINDS NIH HHS K23 NS060660NINDS NIH HHS R01 NS082386NINR NIH HHS R01 NR014181
6 · The paper itself

Abstract

This study examined the reliability of high angular resolution diffusion tensor imaging (HARDI) data collected on a single individual across several sessions using the same scanner. HARDI data was acquired for one healthy adult male at the same time of day on ten separate days across a one-month period. Environmental factors (e.g. temperature) were controlled across scanning sessions. Tract Based Spatial Statistics (TBSS) was used to assess session-to-session variability in measures of diffusion, fractional anisotropy (FA) and mean diffusivity (MD). To address reliability within specific structures of the medial temporal lobe (MTL; the focus of an ongoing investigation), probabilistic tractography segmented the Entorhinal cortex (ERc) based on connections with Hippocampus (HC), Perirhinal (PRc) and Parahippocampal (PHc) cortices. Streamline tractography generated edge weight (EW) metrics for the aforementioned ERc connections and, as comparison regions, connections between left and right rostral and caudal anterior cingulate cortex (ACC). Coefficients of variation (CoV) were derived for the surface area and volumes of these ERc connectivity-defined regions (CDR) and for EW across all ten scans, expecting that scan-to-scan reliability would yield low CoVs. TBSS revealed no significant variation in FA or MD across scanning sessions. Probabilistic tractography successfully reproduced histologically-verified adjacent medial temporal lobe circuits. Tractography-derived metrics displayed larger ranges of scanner-to-scanner variability. Connections involving HC displayed greater variability than metrics of connection between other investigated regions. By confirming the test retest reliability of HARDI data acquisition, support for the validity of significant results derived from diffusion data can be obtained.

Indexed as

Reproducibility of ResultsAdultAnisotropyBrainDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingHumansImage Processing, Computer-AssistedMaleTemporal LobeWhite MatterDiffusion weighted imagingMRI data acquisition reliabilityProbabilistic tractographyStreamline tractographyStructural neuroimagingTract based spatial statistics

Identifiers

PMID26189060
PMCPMC4718901

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.