ArticleEnvironmental toxicology and pharmacology2015
Effect of olfactory manganese exposure on anxiety-related behavior in a mouse model of iron overload hemochromatosis.
Article in Environmental toxicology and pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer's Disease: An Exploratory Study.Journal of clinical medicine · 2022Article
- Elevated transferrin saturation in individuals with alcohol use disorder: Association with HFE polymorphism and alcohol withdrawal severity.Addiction biology · 2022Article
- YAC128 mouse model of Huntington disease is protected against subtle chronic manganese (Mn)-induced behavioral and neuropathological changes.Neurotoxicology · 2021Article
- Alcohol exposure increases manganese accumulation in the brain and exacerbates manganese-induced neurotoxicity in mice.Archives of toxicology · 2021Article
- GLAST Activity is Modified by Acute Manganese Exposure in Bergmann Glial Cells.Neurochemical research · 2020Article
- Manganese attenuates the effects of arsenic on neurobehavioral and biochemical changes in mice co-exposed to arsenic and manganese.Environmental science and pollution research international · 2019Article
- Brain iron loading impairs DNA methylation and alters GABAergic function in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Article
- Influence of iron metabolism on manganese transport and toxicity.Metallomics : integrated biometal science · 2017Review
- Iron overload exacerbates age-associated cardiac hypertrophy in a mouse model of hemochromatosis.Scientific reports · 2017Article
- Mutation in HFE gene decreases manganese accumulation and oxidative stress in the brain after olfactory manganese exposure.Metallomics : integrated biometal science · 2016Article
- Effect of Hfe Deficiency on Memory Capacity and Motor Coordination after Manganese Exposure by Drinking Water in Mice.Toxicological research · 2015Article
- Article
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2 authors at 1 institution in 1 country.
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Abstract
Manganese in excess promotes unstable emotional behavior. Our previous study showed that olfactory manganese uptake into the brain is altered in Hfe(-/-) mice, a model of iron overload hemochromatosis, suggesting that Hfe deficiency could modify the neurotoxicity of airborne manganese. We determined anxiety-related behavior and monoaminergic protein expression after repeated intranasal instillation of MnCl2 to Hfe(-/-) mice. Compared with manganese-instilled wild-type mice, Hfe(-/-) mice showed decreased manganese accumulation in the cerebellum. Hfe(-/-) mice also exhibited increased anxiety with decreased exploratory activity and elevated dopamine D1 receptor and norepinephrine transporter in the striatum. Moreover, Hfe deficiency attenuated manganese-associated impulsivity and modified the effect of manganese on the expression of tyrosine hydroxylase, vesicular monoamine transporter and serotonin transporter. Together, our data indicate that loss of HFE function alters manganese-associated emotional behavior and further suggest that HFE could be a potential molecular target to alleviate affective disorders induced by manganese inhalation.
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