ArticleEuropean archives of psychiatry and clinical neuroscience2015
Postmortem volumetric analysis of the nucleus accumbens in male heroin addicts: implications for deep brain stimulation.
Article in European archives of psychiatry and clinical neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Macroscopic and Microscopic Cerebral Findings in Drug and Alcohol Abusers: The Point of View of the Forensic Pathologist.Biomedicines · 2024Review
- Reduced anterior insular cortex volume in male heroin addicts: a postmortem study.European archives of psychiatry and clinical neuroscience · 2023Article
- Ribosomal DNA transcription is increased in the left nucleus accumbens of heroin-dependent males.European archives of psychiatry and clinical neuroscience · 2022Article
- Nucleus accumbens projections: Validity and reliability of fiber reconstructions based on high-resolution diffusion-weighted MRI.Human brain mapping · 2021Article
- Volumetric data of normal nucleus accumbens from magnetic resonance imaging scans.Medicine and pharmacy reports · 2021Article
- Reduced habenular volumes and neuron numbers in male heroin addicts: a post-mortem study.European archives of psychiatry and clinical neuroscience · 2021Article
- Differential recruitment of ventral pallidal e-types by behaviorally salient stimuli during Pavlovian conditioning.iScience · 2021Article
- The molecular neurobiology and neuropathology of opioid use disorder.Current research in neurobiology · 2021Article
- Opioid and neuroHIV Comorbidity - Current and Future Perspectives.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
- Reduced volumes of the external and internal globus pallidus in male heroin addicts: a postmortem study.European archives of psychiatry and clinical neuroscience · 2019Article
- Total hypothalamic volume is reduced in postmortem brains of male heroin addicts.European archives of psychiatry and clinical neuroscience · 2018Article
- Nucleus accumbens dimensions and surgical precision.European archives of psychiatry and clinical neuroscience · 2016Article
- Unravelling basic mechanisms in addiction and neuropsychiatric disorders.European archives of psychiatry and clinical neuroscience · 2015Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is increasingly investigated in neuropsychiatric disorders. DBS requires computer-assisted 3D planning to implant the stimulation electrode precisely. Recently, there has been a debate about the true dimensions of NAc in healthy as well as in mentally ill individuals. Knowing its true dimensions in different neuropsychiatric disorders may improve even more precise targeting of NAc for therapeutic DBS. Volumes of NAc of heroin addicts (n = 14) and healthy controls (n = 12) were calculated by using morphometry of serial whole-brain sections. Total brain volume was larger in the heroin group (mean 1478.85 ± 62.34 vs. mean 1352.38 ± 103.24 cm(3)), as the heroin group was more than 10 years younger (p = 0.001). However, the mean volume of the NAc in heroin addicts was smaller than in controls (0.528 ± 0.166 vs. 0.623 ± 0.196 cm(3); p = 0.019). This group effect did not significantly differ between the hemispheres. When assessed separately, left-hemispheric NAc volume was 15 % lower (p = 0.020), while right-hemispheric NAc volume was 16 % lower (p = 0.047) in the heroin-addicted group compared to controls. Based on these diagnosis-related differences, we believe it is important to further analyze NAc volumes in different psychiatric disorders to further improve precise targeting and electrode placement.
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