Evidence map›Paper›PMID 26188709›Full record

ArticleAmerican journal of surgery2015

The revised American Joint Committee on Cancer staging system (7th edition) improves prognostic stratification after minimally invasive esophagectomy for esophagogastric adenocarcinoma.

Haris Zahoor, James D Luketich, Benny Weksler, Daniel G Winger, Neil A Christie, Ryan M Levy, Michael K Gibson, Jon M Davison, Katie S Nason

Abstract read
In one paragraph

Article in American journal of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Recommendations for pathologic staging (pTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2016
    Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haris ZahoorDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
James D LuketichDepartment of Cardiothoracic Surgery, University of Pittsburgh, 5200 Centre Ave, Suite 715, Shadyside Medical Building, Pittsburgh, PA 15232, USA.
Benny WekslerDivision of Cardiothoracic Surgery, University of Tennessee Health Science Center, Memphis, TN, USA.
Daniel G WingerClinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Neil A ChristieDepartment of Cardiothoracic Surgery, University of Pittsburgh, 5200 Centre Ave, Suite 715, Shadyside Medical Building, Pittsburgh, PA 15232, USA.
Ryan M LevyDepartment of Cardiothoracic Surgery, University of Pittsburgh, 5200 Centre Ave, Suite 715, Shadyside Medical Building, Pittsburgh, PA 15232, USA.
Michael K GibsonDivision of Hematology and Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Jon M DavisonDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
Katie S NasonDepartment of Cardiothoracic Surgery, University of Pittsburgh, 5200 Centre Ave, Suite 715, Shadyside Medical Building, Pittsburgh, PA 15232, USA. Electronic address: nasonks@upmc.edu.

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Barriers to Early Detection of Esophageal AdenocarcinomaK07CA151613 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NASON, KATIE S · 2011 to 2015
$818k
NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1TR000005NCI NIH HHS K07 CA151613NCI NIH HHS K07CA511613NCI NIH HHS L30 CA179766NCRR NIH HHS UL1 RR024153
6 · The paper itself

Abstract

backgroundStaging for esophagogastric adenocarcinoma lacked sufficient prognostic accuracy and was revised. We compared survival prognostication between American Joint Committee on Cancer (AJCC) 6th and 7th editions.

methodsWe abstracted data for 836 patients who underwent minimally invasive esophagectomy for esophagogastric adenocarcinoma (n = 256 neoadjuvant). Monotonicity and strength of survival trends, by stage, were assessed (log-rank test of trend chi-square statistic) and compared using permutation testing. Overall survival (Cox regression) and model fit (Akaike Information Criterion) were determined.

resultsA greater log-rank test of trend statistic indicated stronger survival trends by stage in AJCC 7th (152.872 vs 167.623; permutation test P < .001) edition. Greater Cox likelihood chi-square value (162.957 vs 173.951) and lower Akaike Information Criterion (4,831.011 vs 4,820.016) indicated better model fit. Superior performance was also shown after neoadjuvant therapy.

conclusionAJCC 7th edition staging for esophagogastric adenocarcinoma provides superior prognostic stratification after minimally invasive esophagectomy, overall and after neoadjuvant therapy compared with AJCC 6th edition.

Indexed as

EsophagectomyEsophagogastric JunctionLaparoscopyNeoplasm StagingAdenocarcinomaAgedCohort StudiesEsophageal NeoplasmsFemaleHumansMaleMiddle AgedNeoadjuvant TherapyPredictive Value of TestsPrognosisSurvival RateAdenocarcinomaEsophageal neoplasmsEsophagectomyNeoplasmStagingSurvival

Identifiers

PMID26188709
PMCPMC4575853

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.