Evidence map›Paper›PMID 26188469›Full record

ReviewCurrent opinion in structural biology2015

Structural and genetic diversity in antibody repertoires from diverse species.

Miguel de los Rios, Michael F Criscitiello, Vaughn V Smider

Abstract readReview
In one paragraph

Review in Current opinion in structural biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Article
  2. Article
  3. IMGTAntibodies (Basel, Switzerland) · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Animal Models of Human Disease 2.0.International journal of molecular sciences · 2024
    Article
  9. Characteristics and Genomic Localization of Nurse Shark (International journal of molecular sciences · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Structural Classification of CDR-H3 in Single-Domain VMethods in molecular biology (Clifton, N.J.) · 2023
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Miguel de los RiosFabrus Inc., A Division of Sevion Therapeutics, San Diego, CA 92121, United States.
Michael F CriscitielloDepartment of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, United States.
Vaughn V SmiderFabrus Inc., A Division of Sevion Therapeutics, San Diego, CA 92121, United States; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.

Funding

Molecular and Structural Studies of Antibody Diversity MechanismsR01GM105826 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SMIDER, VAUGHN VASIL · 2014 to 2021
$3.1M
NIGMS NIH HHS 1R01GM105826-01A1NIGMS NIH HHS R01 GM105826
6 · The paper itself

Abstract

The antibody repertoire is the fundamental unit that enables development of antigen specific adaptive immune responses against pathogens. Different species have developed diverse genetic and structural strategies to create their respective antibody repertoires. Here we review the shark, chicken, camel, and cow repertoires as unique examples of structural and genetic diversity. Given the enormous importance of antibodies in medicine and biological research, the novel properties of these antibody repertoires may enable discovery or engineering of antibodies from these non-human species against difficult or important epitopes.

Indexed as

Genetic VariationAmino Acid SequenceAnimalsAntibodiesCamelusCattleChickensHumansMolecular Sequence DataProtein ConformationSharksAntibodies

Identifiers

PMID26188469
PMCPMC7039331

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.