ArticleAddictive behaviors2015
Smoking cessation behaviors three months following acute insular damage from stroke.
Article in Addictive behaviors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Efficacy and Neural Mechanisms of Mindfulness Meditation Among Adults With Internet Gaming Disorder: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula.Neuromodulation : journal of the International Neuromodulation Society · 2019Trial
- A cortical insula-orbitofrontal circuit drives stress-induced dopamine system dysfunction.Molecular psychiatry · 2026Article
- Reconsidering Ondansetron for Smoking Cessation: A Call for Renewed Investigation.Pharmacology research & perspectives · 2025Article
- The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference.Psychopharmacology · 2024Article
- An Unexpected Outcome of an Ischemic Stroke on the Reward Pathways in the Human Brain.HCA healthcare journal of medicine · 2024Article
- PET imaging of kappa opioid receptors and receptor expression quantified in neuron-derived extracellular vesicles in socially housed female and male cynomolgus macaques.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Brain lesions disrupting addiction map to a common human brain circuit.Nature medicine · 2022Article
- Decreased excitability of leptin-sensitive anterior insula pyramidal neurons in a rat model of compulsive food demand.Neuropharmacology · 2022Article
- Multi-omics analysis reveals GABAergic dysfunction after traumatic brainstem injury in rats.Frontiers in neuroscience · 2022Article
- Reduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting.NeuroImage. Clinical · 2022Article
- Targeting the Salience Network: A Mini-Review on a Novel Neuromodulation Approach for Treating Alcohol Use Disorder.Frontiers in psychiatry · 2022Review
- Precision Preventive Medicine of Relapse in Smoking Cessation: Can MRI Inform the Search of Intermediate Phenotypes?Biology · 2021Review
- Nicotine Exposure during Adolescence Leads to Changes of Synaptic Plasticity and Intrinsic Excitability of Mice Insular Pyramidal Cells at Later Life.International journal of molecular sciences · 2021Article
- The insula in nicotine use disorder: Functional neuroimaging and implications for neuromodulation.Neuroscience and biobehavioral reviews · 2019Review
- Implications of insular cortex laterality for treatment of nicotine addiction.Drug and alcohol dependence · 2019Article
- The Insula: A Brain Stimulation Target for the Treatment of Addiction.Frontiers in pharmacology · 2019Review
- Synaptic Plasticity in the Bed Nucleus of the Stria Terminalis: Underlying Mechanisms and Potential Ramifications for Reinstatement of Drug- and Alcohol-Seeking Behaviors.ACS chemical neuroscience · 2018Article
- Immediate and Sustained Decrease in Smoking Urges After Acute Insular Cortex Damage.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Observational
- Resting-State Functional Connectivity of the Basal Nucleus of Meynert in Cigarette Smokers: Dependence Level and Gender Differences.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundRecent evidence suggests that the insular cortex may play an important role in cognitive and emotional processes that facilitate drug use but it is unclear whether changes to the insula would result in sustained abstinence. To better understand the role of the insula in maintaining abstinence, we examined quitting patterns in smokers with acute damage to their insula relative to other regions.
designProspective cohort study with 3month follow-up, beginning June 2013 and ending May 2014.
settingThree acute care hospitals in Rochester, NY.
participantsOne-hundred-fifty-six current smokers hospitalized for acute ischemic stroke; 38 with insular infarctions and 118 with non-insular infarctions, assessed by 3 neuroradiologists. MEASUREMENTS: Self-reported smoking status (seven-day point prevalence and continuous abstinence), complete abstinence from any nicotine product, and disruption of smoking addiction (defined by criteria on smoking status, difficulty of quitting, and urge) were assessed at three months post-stroke. Time to relapse (in days) after discharge was also assessed.
resultsInsular damage was associated with increased odds of three-month continuous abstinence (OR=3.71, 95% CI: 1.59, 8.65) and complete cessation from any nicotine product (OR=2.72, 95% CI: 1.19, 6.22). Average time to relapse was longer in the insular-damaged group (17.50days, SD=19.82) relative to non-insular damage (10.42days, SD=18.49). Among quitters, insular damage was also associated with higher relative odds of experiencing a disruption of addiction compared to non-insular damage (adjusted OR=5.60, 95% CI: 1.52, 20.56).
conclusionsThese findings support the potential role of the insular cortex in maintaining smoking and nicotine abstinence. Further research is needed to establish whether the insula may be a novel target for smoking cessation interventions.
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