ArticleActa tropica2015
The population genetics of Trypanosoma cruzi revisited in the light of the predominant clonal evolution model.
Article in Acta tropica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- An Overview ofPathogens (Basel, Switzerland) · 2025Review
- Review
- Dissimilar Trypanosoma cruzi genotype-specific serological profile assessed by Chagas-Flow ATE IgG1 upon benznidazole etiological treatment of chronic Chagas disease.PLoS neglected tropical diseases · 2024Article
- Genome plasticity driven by aneuploidy and loss of heterozygosity inMicrobial genomics · 2022Article
- Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review.Pathogens (Basel, Switzerland) · 2021Review
- Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia.Scientific reports · 2021Article
- AssessingPathogens (Basel, Switzerland) · 2021Article
- Intra-Discrete Typing Unit TcV Genetic Variability ofFrontiers in cardiovascular medicine · 2021Article
- Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen,Frontiers in cellular and infection microbiology · 2021Article
- Transcriptional remodeling during metacyclogenesis inVirulence · 2020Article
- Review
- Human Chagas-Flow ATE-IgG1 for advanced universal and Trypanosoma cruzi Discrete Typing Units-specific serodiagnosis of Chagas disease.Scientific reports · 2020Article
- Quantification of parasite burden of Trypanosoma cruzi and identification of Discrete Typing Units (DTUs) in blood samples of Latin American immigrants residing in Barcelona, Spain.PLoS neglected tropical diseases · 2020Article
- Evidence of hybridization, mitochondrial introgression and biparental inheritance of the kDNA minicircles in Trypanosoma cruzi I.PLoS neglected tropical diseases · 2020Article
- Trypanosoma cruzi diversity in naturally infected nonhuman primates in Louisiana assessed by deep sequencing of the mini-exon gene.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2019Article
- The recombinase Rad51 plays a key role in events of genetic exchange in Trypanosoma cruzi.Scientific reports · 2018Article
- Evolutionary ecology of Chagas disease; what do we know and what do we need?Evolutionary applications · 2018Review
- Phenotypic diversity and drug susceptibility of Trypanosoma cruzi TcV clinical isolates.PloS one · 2018Article
- New insights into Trypanosoma cruzi evolution, genotyping and molecular diagnostics from satellite DNA sequence analysis.PLoS neglected tropical diseases · 2017Article
- Cytochrome c oxidase subunit 1 gene as a DNA barcode for discriminating Trypanosoma cruzi DTUs and closely related species.Parasites & vectors · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparing the population structure of Trypanosoma cruzi with that of other pathogens, including parasitic protozoa, fungi, bacteria and viruses, shows that the agent of Chagas disease shares typical traits with many other species, related to a predominant clonal evolution (PCE) pattern: statistically significant linkage disequilibrium, overrepresented multilocus genotypes, near-clades (genetic subdivisions somewhat blurred by occasional genetic exchange/hybridization) and "Russian doll" patterns (PCE is observed, not only at the level of the whole species, but also, within the near-clades). Moreover, T. cruzi population structure exhibits linkage with the diversity of several strongly selected genes, with gene expression profiles, and with some major phenotypic traits. We discuss the evolutionary significance of these results, and their implications in terms of applied research (molecular epidemiology/strain typing, analysis of genes of interest, vaccine and drug design, immunological diagnosis) and of experimental evolution. Lastly, we revisit the long-term debate of describing new species within the T. cruzi taxon.
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