SynthesisAmerican journal of epidemiology2015
Hospitalization Fatality Risk of Influenza A(H1N1)pdm09: A Systematic Review and Meta-Analysis.
Synthesis in American journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Influenza A Virus (H1N1) Infection Induces Ferroptosis to Promote Developmental Injury in Fetal Tissues.Cell proliferation · 2026Pooled it
- Virucidal efficacy of chlorhexidine: a systematic review.Odontology · 2022Pooled it
- Case-fatality risk of pregnant women with acute viral hepatitis type E: a systematic review and meta-analysis.Epidemiology and infection · 2016Pooled it
- Respiratory Syncytial Virus Suppression through Public Health and Social Measures, Hong Kong, China, 2020-2023.Emerging infectious diseases · 2026Article
- Evaluating modes of influenza transmission (EMIT-2): Insights from lack of transmission in a controlled transmission trial with naturally infected donors.PLoS pathogens · 2026Article
- Evaluating Modes of Influenza Transmission (EMIT-2): Insights from a Controlled Human Influenza Virus Infection Transmission Trial (CHIVITT).medRxiv : the preprint server for health sciences · 2025Article
- Hospitalizations and In-Hospital Fatality Among Influenza Patients in the Pre-Pandemic and COVID-19 Pandemic Periods.Journal of clinical medicine · 2025Article
- The genetic diversity, replication, and transmission of 2009 pandemic H1N1 viruses in China.Frontiers in microbiology · 2023Article
- Review
- Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China.Nature communications · 2020Article
- Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China.medRxiv : the preprint server for health sciences · 2020Article
- Case fatality risk of novel coronavirus diseases 2019 in China.medRxiv : the preprint server for health sciences · 2020Article
- Inpatient hospital fatality related to coding (ICD-9-CM) of the influenza diagnosis in Spain (2009-2015).BMC infectious diseases · 2019Article
- Influenza Infections and Emergent Viral Infections in Intensive Care Unit.Seminars in respiratory and critical care medicine · 2019Review
- Comparison of the nasopharynx microbiome between influenza and non-influenza cases of severe acute respiratory infections: A pilot study.Health science reports · 2018Article
- Factors associated with influenza vaccination failure and severe disease in a French region in 2015.PloS one · 2018Article
- A global perspective on hepatitis B-related single nucleotide polymorphisms and evolution during human migration.Hepatology communications · 2017Article
- B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Modernising epidemic science: enabling patient-centred research during epidemics.BMC medicine · 2016Article
- Involvement of the different lung compartments in the pathogenesis of pH1N1 influenza virus infection in ferrets.Veterinary research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
During the 2009 influenza pandemic, uncertainty surrounding the severity of human infections with the influenza A(H1N1)pdm09 virus hindered the calibration of the early public health response. The case fatality risk was widely used to assess severity, but another underexplored and potentially more immediate measure is the hospitalization fatality risk (HFR), defined as the probability of death among H1N1pdm09 cases who required hospitalization for medical reasons. In this review, we searched for relevant studies published in MEDLINE (PubMed) and EMBASE between April 1, 2009, and January 9, 2014. Crude estimates of the HFR ranged from 0% to 52%, with higher estimates from tertiary-care referral hospitals in countries with a lower gross domestic product, but in wealthy countries the estimate was 1%-3% in all settings. Point estimates increased substantially with age and with lower gross domestic product. Early in the next pandemic, estimation of a standardized HFR may provide a picture of the severity of infection, particularly if it is presented in comparison with a similarly standardized HFR for seasonal influenza in the same setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.