ArticleNeuropharmacology2015
Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala.
Article in Neuropharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.
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Who cites it
126 citing papers in PubMed, 172 citations in OpenAlex.
- Anterior cingulate cortex activation of claustrum projection neuron subtypes is enhanced by alcohol.Neuropharmacology · 2026Article
- Functional interaction between orexin/CRF and orexin/dynorphin transmission in the infralimbic cortex modulates the stress-induced reinstatement of alcohol-seeking behavior in male and female Wistar rats.Neuropharmacology · 2026Article
- Chronic ethanol exposure reduces resting state functional connectivity and regional synchrony in male rats.Psychopharmacology · 2026Article
- Impact of chronic alcohol and stress on midlife cognition and locus coeruleus integrity in mice.Alcohol, clinical & experimental research · 2026Article
- Sex differences in low-dose ethanol effects on motivated behavior and limbic corticostriatal activity in mice.Alcohol, clinical & experimental research · 2026Article
- Activation of GLP-1R ameliorates alcohol withdrawal induced anxiety-like behavior by regulating neuronal mitochondrial quality control.Frontiers in pharmacology · 2026Article
- Impact of chronic alcohol and stress on mid-life cognition and locus coeruleus integrity.bioRxiv : the preprint server for biology · 2025Article
- Sex Differences in Low-dose Ethanol Effects on Motivated Behavior and Limbic Corticostriatal Activity.bioRxiv : the preprint server for biology · 2025Article
- Alcohol consumption drives sex- and region- specific disruption of somatostatin signaling in mice.bioRxiv : the preprint server for biology · 2025Article
- Repeated cycles of binge-like ethanol consumption and abstinence alter neuropeptide mRNA in prefrontal and insular cortex, amygdala, and lateral hypothalamus of male and female C57BL/6J mice.Alcohol, clinical & experimental research · 2025Article
- Effect of chronic alcohol exposure and single-prolonged stress on conditioned fear behavior.Behavioural brain research · 2025Article
- Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025Review
- Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice.Neurobiology of aging · 2025Article
- Alcohol, flexible behavior, and the prefrontal cortex: Functional changes underlying impaired cognitive flexibility.Neuropharmacology · 2024Review
- Oxytocin as a treatment for alcohol use disorder and heavy drinking: A narrative review.Experimental and clinical psychopharmacology · 2024Review
- Chronic ethanol exposure produces long-lasting, subregion-specific physiological adaptations in RMTg-projecting mPFC neurons.Neuropharmacology · 2024Article
- Interaction between corticotropin-releasing factor, orexin, and dynorphin in the infralimbic cortex may mediate exacerbated alcohol-seeking behavior.Neurobiology of stress · 2024Article
- Pre- and postsynaptic signatures in the prelimbic cortex associated with "alcohol use disorder" in the rat.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Withdrawal from chronic alcohol impairs the serotonin-mediated modulation of GABAergic transmission in the infralimbic cortex in male rats.Neurobiology of disease · 2024Article
- Functional and morphological adaptation of medial prefrontal corticotropin releasing factor receptor 1-expressing neurons in male mice following chronic ethanol exposure.Neurobiology of stress · 2024Article
66 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic alcohol consumption and withdrawal leads to anxiety, escalated alcohol drinking behavior, and alcohol dependence. Alterations in the function of key structures within the cortico-limbic neural circuit have been implicated in underlying the negative behavioral consequences of chronic alcohol exposure in both humans and rodents. Here, we used chronic intermittent ethanol vapor exposure (CIE) in male C57BL/6J mice to evaluate the effects of chronic alcohol exposure and withdrawal on anxiety-like behavior and basal synaptic function and neuronal excitability in prefrontal cortical and extended amygdala brain regions. Forty-eight hours after four cycles of CIE, mice were either assayed in the marble burying test (MBT) or their brains were harvested and whole-cell electrophysiological recordings were performed in the prelimbic and infralimbic medial prefrontal cortex (PLC and ILC), the lateral and medial central nucleus of the amygdala (lCeA and mCeA), and the dorsal and ventral bed nucleus of the stria terminalis (dBNST and vBNST). Ethanol-exposed mice displayed increased anxiety in the MBT compared to air-exposed controls, and alterations in neuronal function were observed in all brain structures examined, including several distinct differences between subregions within each structure. Chronic ethanol exposure induced hyperexcitability of the ILC, as well as a shift toward excitation in synaptic drive and hyperexcitability of vBNST neurons; in contrast, there was a net inhibition of the CeA. This study reveals extensive effects of chronic ethanol exposure on the basal function of cortico-limbic brain regions, suggests that there may be complex interactions between these regions in the regulation of ethanol-dependent alterations in anxiety state, and highlights the need for future examination of projection-specific effects of ethanol in cortico-limbic circuitry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.