ArticleNeuropharmacology2015
Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking.
Article in Neuropharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- G protein-dependent dopamine D2 receptor signaling mediates cocaine-primed reinstatement.Acta pharmacologica Sinica · 2026Article
- The role of dorsal raphe nucleus neuropeptides in reward and aversion.Frontiers in behavioral neuroscience · 2025Review
- Neurokinin-1 receptors in the nucleus accumbens shell influence sensitivity to social defeat stress and stress-induced alcohol consumption in male mice.Addiction neuroscience · 2024Article
- CRF regulates pain sensation by enhancement of corticoaccumbal excitatory synaptic transmission.Molecular psychiatry · 2024Article
- Vicarious defeat stress induces increased alcohol consumption in female mice: Role of neurokinin-1 receptor and interleukin-6.Addiction biology · 2024Article
- The effects of lipopolysaccharide exposure on social interaction, cytokine expression, and alcohol consumption in male and female mice.Physiology & behavior · 2023Article
- Live predator stress in adolescence results in distinct adult behavioral consequences and dorsal diencephalic brain activation patterns.Behavioural brain research · 2021Article
- Cocaine and amphetamine regulated transcript (CART) signalling in the central nucleus of the amygdala modulates stress-induced alcohol seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Sex differences in oral oxycodone self-administration and stress-primed reinstatement in rats.Addiction biology · 2020Article
- Neurokinin receptors in drug and alcohol addiction.Brain research · 2020Review
- Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis.Handbook of behavioral neuroscience · 2020Article
- Article
- A Motivational and Neuropeptidergic Hub: Anatomical and Functional Diversity within the Nucleus Accumbens Shell.Neuron · 2019Review
- Common neurocircuitry mediating drug and fear relapse in preclinical models.Psychopharmacology · 2019Review
- Anti-stress neuropharmacological mechanisms and targets for addiction treatment: A translational framework.Neurobiology of stress · 2018Review
- What does the Fos say? Using Fos-based approaches to understand the contribution of stress to substance use disorders.Neurobiology of stress · 2018Review
- The neurokinin-1 receptor mediates escalated alcohol intake induced by multiple drinking models.Neuropharmacology · 2018Article
- Bidirectional relationship between alcohol intake and sensitivity to social defeat: association with Tacr1 and Avp expression.Addiction biology · 2018Article
- Central amygdala relaxin-3/relaxin family peptide receptor 3 signalling modulates alcohol seeking in rats.British journal of pharmacology · 2017Article
- The GABANeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Substance P (SP) and its cognate neurokinin-1 receptor (NK1R) are involved in alcohol-related behaviors. We have previously reported that NK1R antagonism attenuates stress-induced reinstatement of alcohol seeking and suppresses escalated alcohol self-administration, but does not affect primary reinforcement or cue-induced reinstatement. Here, we administered an NK1R antagonist or vehicle prior to footshock-induced reinstatement of alcohol seeking, and mapped the resulting neuronal activation using Fos immunohistochemistry. As expected, vehicle treated animals exposed to footshock showed induction of Fos immunoreactivity in several regions of the brain stress circuitry, including the amygdala (AMG), nucleus accumbens (NAC), dorsal raphe nucleus (DR), prefrontal cortex (PFC), and bed nucleus of the stria terminalis (BNST). NK1R antagonism selectively suppressed the stress-induced increase in Fos in the DR and NAC shell. In the DR, Fos-induction by stress largely overlapped with tryptophan hydroxylase (TrpH), indicating activation of serotonergic neurons. Of NAC shell neurons activated during stress-induced reinstatement of alcohol seeking, about 30% co-expressed dynorphin (DYN), while 70% co-expressed enkephalin (ENK). Few (<1%) activated NAC shell neurons coexpressed choline acetyltransferase (ChAT), which labels the cholinergic interneurons of this region. Infusion of the NK1R antagonist L822429 into the NAC shell blocked stress-induced reinstatement of alcohol seeking. In contrast, L822429 infusion into the DR had no effect, suggesting that the influence of NK1R signaling on neuronal activity in the DR is indirect. Taken together, our results outline a potential pathway through which endogenous NK1R activation mediates stress-induced alcohol seeking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.