ArticleApplied and environmental microbiology2015
A Complex Signaling Cascade Governs Pristinamycin Biosynthesis in Streptomyces pristinaespiralis.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Bacterial biosynthetic superclusters: emerging drivers of synergistic natural products against antimicrobial resistance.Essays in biochemistry · 2026Review
- Engineering Streptomyces sp. CPCC 204095 for the targeted high-level production of isatropolone A by elucidating its pathway-specific regulatory mechanism.Microbial cell factories · 2024Article
- Type IV secretion system effector sabotages multiple defense systems in a competing bacterium.The ISME journal · 2024Article
- Challenging old microbiological treasures for natural compound biosynthesis capacity.Frontiers in bioengineering and biotechnology · 2024Article
- The roles of SARP family regulators involved in secondary metabolism inFrontiers in microbiology · 2024Review
- Biotransformation-coupled mutasynthesis for the generation of novel pristinamycin derivatives by engineering the phenylglycine residue.RSC chemical biology · 2023Article
- Functional investigation of AfsKRS regulatory system for pristinamycin biosynthesis in3 Biotech · 2021Article
- Regulatory Control of Rishirilide(s) Biosynthesis inMicroorganisms · 2021Article
- The Streptomyces filipinensis Gamma-Butyrolactone System Reveals Novel Clues for Understanding the Control of Secondary Metabolism.Applied and environmental microbiology · 2020Article
- Coordinated regulation for nature products discovery and overproduction inSynthetic and systems biotechnology · 2020Article
- Genetic engineering approaches for the fermentative production of phenylglycines.Applied microbiology and biotechnology · 2020Article
- The regulatory cascades of antibiotic production in Streptomyces.World journal of microbiology & biotechnology · 2020Review
- Investigation of the Autoregulator-Receptor System in the Pristinamycin ProducerFrontiers in microbiology · 2020Article
- Disclosing the Potential of the SARP-Type Regulator PapR2 for the Activation of Antibiotic Gene Clusters in Streptomycetes.Frontiers in microbiology · 2020Article
- The Application of Regulatory Cascades inFrontiers in microbiology · 2020Review
- Corrigendum: The Application of Regulatory Cascades inFrontiers in microbiology · 2020Article
- Actinomycete-Derived Polyketides as a Source of Antibiotics and Lead Structures for the Development of New Antimicrobial Drugs.Antibiotics (Basel, Switzerland) · 2019Review
- Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges.Synthetic and systems biotechnology · 2018Review
- Regulatory genes and their roles for improvement of antibiotic biosynthesis in Streptomyces.3 Biotech · 2017Review
- Improvement of pristinamycin I (PI) production inSynthetic and systems biotechnology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pristinamycin production in Streptomyces pristinaespiralis Pr11 is tightly regulated by an interplay between different repressors and activators. A γ-butyrolactone receptor gene (spbR), two TetR repressor genes (papR3 and papR5), three SARP (Streptomyces antibiotic regulatory protein) genes (papR1, papR2, and papR4), and a response regulator gene (papR6) are carried on the large 210-kb pristinamycin biosynthetic gene region of Streptomyces pristinaespiralis Pr11. A detailed investigation of all pristinamycin regulators revealed insight into a complex signaling cascade, which is responsible for the fine-tuned regulation of pristinamycin production in S. pristinaespiralis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.