Evidence map›Paper›PMID 26187892›Full record

ArticlePathogens and disease2015

A putative, novel coli surface antigen 8B (CS8B) of enterotoxigenic Escherichia coli.

Samuel M Njoroge, Christine J Boinett, Laure F Madé, Tom T Ouko, Eric M Fèvre, Nicholas R Thomson, Samuel Kariuki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens and disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Chaperone-Usher Pili Loci of Colonization Factor-Negative Human EnterotoxigenicFrontiers in cellular and infection microbiology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samuel M NjorogeCentre for Microbiology Research, Kenya Medical Research Institute, PO Box 43640-00100 Nairobi, Kenya.
Christine J BoinettWellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Laure F MadéInstitute of Infection and Global Health, University of Liverpool, Liverpool L69 7BE, UK International Livestock Research Institute, PO Box 30709-00100, Nairobi, Kenya.
Tom T OukoCentre for Microbiology Research, Kenya Medical Research Institute, PO Box 43640-00100 Nairobi, Kenya.
Eric M FèvreInstitute of Infection and Global Health, University of Liverpool, Liverpool L69 7BE, UK International Livestock Research Institute, PO Box 30709-00100, Nairobi, Kenya.
Nicholas R ThomsonWellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Samuel KariukiCentre for Microbiology Research, Kenya Medical Research Institute, PO Box 43640-00100 Nairobi, Kenya Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK samkariuki2@gmail.com.

Funding

Biotechnology and Biological Sciences Research Council G1100783/1Medical Research Council G1100100Medical Research Council G1100100/1Medical Research Council G1100783Wellcome Trust 098051
6 · The paper itself

Abstract

Enterotoxigenic Escherichia coli (ETEC) strains harbor multiple fimbriae and pili to mediate host colonization, including the type IVb pilus, colonization factor antigen III (CFA/III). Not all colonization factors are well characterized or known in toxin positive ETEC isolates, which may have an impact identifying ETEC isolates based on molecular screening of these biomarkers. We describe a novel coli surface antigen (CS) 8 subtype B (CS8B), a family of CFA/III pilus, in a toxin producing ETEC isolate from a Kenyan collection. In highlighting the existence of this putative CS, we provide the sequence and specific primers, which can be used alongside other ETEC primers previously described.

Indexed as

Antigens, SurfaceChild, PreschoolDNA, BacterialDNA PrimersEnterotoxigenic Escherichia coliEscherichia coli InfectionsEscherichia coli ProteinsFimbriae, BacterialHumansInfantInfant, NewbornKenyaMolecular Sequence DataSequence Analysis, DNAAntigens, SurfaceDNA, BacterialDNA PrimersEscherichia coli Proteinscoli surface antigen 8 subtype Bcolonization factorsEnterotoxigenic Escherichia coliKenyatype IVb pilins

Identifiers

PMID26187892
PMCPMC4535451

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.