Evidence map›Paper›PMID 26187703›Full record

ArticleAnnals of vascular surgery2016

Mortality and Cost of Acute and Chronic Kidney Disease after Vascular Surgery.

Matthew Huber, Tezcan Ozrazgat-Baslanti, Paul Thottakkara, Philip A Efron, Robert Feezor, Charles Hobson, Azra Bihorac

Open access · greenAbstract read
In one paragraph

Article in Annals of vascular surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Matthew HuberDepartment of Anesthesiology, University of Florida, Gainesville, FL.
Tezcan Ozrazgat-BaslantiDepartment of Anesthesiology, University of Florida, Gainesville, FL.
Paul ThottakkaraDepartment of Anesthesiology, University of Florida, Gainesville, FL.
Philip A EfronDepartment of Surgery, University of Florida, Gainesville, FL.
Robert FeezorDepartment of Surgery, University of Florida, Gainesville, FL.
Charles HobsonDepartment of Surgery, Malcom Randall VA Medical Center, Gainesville, FL; Department of Health Services Research, Management, and Policy, University of Florida, Gainesville, FL.
Azra BihoracDepartment of Anesthesiology, University of Florida, Gainesville, FL. Electronic address: abihorac@anest.ufl.edu.
University of Florida · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
PICS: A New Horizon for Surgical Critical CareP50GM111152 · NIGMS · UNIVERSITY OF FLORIDA · PI MOORE, FREDERICK A · 2014 to 2018
$10.7M
Integrating data, algorithms and clinical reasoning for surgical risk assessmentR01GM110240 · NIGMS · UNIVERSITY OF FLORIDA · PI BIHORAC, AZRA, RASHIDI, PARISA · 2016 to 2025
$5.1M
Hematopoietic Stem Cell Dysfunction in the Elderly after Severe InjuryR01GM113945 · NIGMS · UNIVERSITY OF FLORIDA · PI EFRON, PHILIP A · 2015 to 2019
$1.6M
NCATS NIH HHS UL1 TR001427NIA NIH HHS P30 AG028740NIGMS NIH HHS P50 GM-111152NIGMS NIH HHS P50 GM111152NIGMS NIH HHS R01 GM110240NIGMS NIH HHS R01 GM113945
6 · The paper itself

Abstract

backgroundBoth acute kidney injury (AKI) and chronic kidney disease (CKD) are common yet underappreciated risk factors for adverse perioperative outcomes. We hypothesize that AKI and CKD are associated with similar increases in 90-day mortality and cost in patients undergoing major vascular surgery.

methodsWe used multivariable regression analyses to evaluate the associations between AKI and CKD and incremental 90-day mortality and hospital cost in a single-center cohort of 3646 adult patients undergoing major vascular surgery. We defined AKI using Kidney Disease: Improving Global Outcomes criteria as change in creatinine ≥ 0.3 mg/dL or ≥ 50% increase from the reference value. CKD was determined from medical history. Regression models were adjusted for demographic and socioeconomic characteristics, comorbid conditions, surgery type, and postoperative complications.

resultsThe prevalence of kidney disease among vascular surgery patients is high with 49% of patients developing AKI during hospitalization and 17% presenting with CKD on admission. In risk-adjusted logistic regression analysis, perioperative AKI (odds ratio 2.2, 95% confidence interval 1.5-3.3) was the most significant predictor of 90-day mortality. The risk-adjusted average cost was significantly higher for patients with any type of kidney disease. The incremental cost of having any type of kidney disease ranged from $9100 to $19,100, even after adjustment for underlying comorbidities and other postoperative complications.

conclusionsKidney disease after major vascular surgery is associated with significant increases in 90-day mortality and cost with the highest risk observed among patients with AKI regardless of previous CKD.

Indexed as

Hospital CostsAcute Kidney InjuryAdultAgedCohort StudiesCritical CareFemaleHospitalizationHospital MortalityHumansLogistic ModelsMaleMiddle AgedPrevalenceRenal Insufficiency, ChronicRisk Factors

Identifiers

PMID26187703
PMCPMC4691411
OpenAlexW872746627

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.