ArticleBMC biology2015
Control of Caenorhabditis elegans germ-line stem-cell cycling speed meets requirements of design to minimize mutation accumulation.
Article in BMC biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Analysis of the C. elegans Germline Stem Cell Pool.Methods in molecular biology (Clifton, N.J.) · 2023Article
- More than just a pool.eLife · 2020Article
- Recent Advances in the Genetic, Anatomical, and Environmental Regulation of theJournal of developmental biology · 2020Review
- Live-imaging analysis of germ cell proliferation in the C. elegans adult supports a stochastic model for stem cell proliferation.Developmental biology · 2017Article
- How computational models contribute to our understanding of the germ line.Molecular reproduction and development · 2016Review
- Quantification of in vivo progenitor mutation accrual with ultra-low error rate and minimal input DNA using SIP-HAVA-seq.Genome research · 2016Article
- Article
- Intermittent Stem Cell Cycling Balances Self-Renewal and Senescence of the C. elegans Germ Line.PLoS genetics · 2016Article
- Cell cycle features of C. elegans germline stem/progenitor cells vary temporally and spatially.Developmental biology · 2016Article
- Analysis of in vivo single cell behavior by high throughput, human-in-the-loop segmentation of three-dimensional images.BMC bioinformatics · 2015Article
- Semi-permeable Diffusion Barriers Enhance Patterning Robustness in the C. elegans Germline.Developmental cell · 2015Article
- Mechano-logical model of C. elegans germ line suggests feedback on the cell cycle.Development (Cambridge, England) · 2015Article
- Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch.eLife · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundStem cells are thought to play a critical role in minimizing the accumulation of mutations, but it is not clear which strategies they follow to fulfill that performance objective. Slow cycling of stem cells provides a simple strategy that can minimize cell pedigree depth and thereby minimize the accumulation of replication-dependent mutations. Although the power of this strategy was recognized early on, a quantitative assessment of whether and how it is employed by biological systems is missing.
resultsHere we address this problem using a simple self-renewing organ - the C. elegans gonad - whose overall organization is shared with many self-renewing organs. Computational simulations of mutation accumulation characterize a tradeoff between fast development and low mutation accumulation, and show that slow-cycling stem cells allow for an advantageous compromise to be reached. This compromise is such that worm germ-line stem cells should cycle more slowly than their differentiating counterparts, but only by a modest amount. Experimental measurements of cell cycle lengths derived using a new, quantitative technique are consistent with these predictions.
conclusionsOur findings shed light both on design principles that underlie the role of stem cells in delaying aging and on evolutionary forces that shape stem-cell gene regulatory networks.
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