ArticleBMC complementary and alternative medicine2015
Antidiabetic activities of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin-induced diabetic rats.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 91 citations in OpenAlex.
- Facility-based prospective cohort study to evaluate Moringa stenopetala based diet consumption in management of diabetes and hypertension in South Ethiopia.Scientific reports · 2026Article
- Impacts of Herbal Medicine Use on Lipid Profiles in Type 2 Diabetic Patients in Northwest Ethiopia: A Comparative Cross-Sectional Study.BioMed research international · 2026Article
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- Tauroursodeoxycholic Acid (TUDCA) Relieves Streptozotocin (STZ)-Induced Diabetic Rat Model via Modulation of Lipotoxicity, Oxidative Stress, Inflammation, and Apoptosis.International journal of molecular sciences · 2024Article
- Evaluation of antioxidant and antihyperglycemic effectsMetabolism open · 2024Article
- Mitigation of Diabetes Mellitus UsingJournal of diabetes research · 2024Article
- Anti-Diabetic Effects of the 80% Methanolic Extract of Datura Stramonium Linn (Solanaceae) Leaves in Streptozotocin- Induced Diabetic Mice.Journal of experimental pharmacology · 2023Article
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- In vitro Anti-Leishmanial Activities of Methanol Extract ofJournal of experimental pharmacology · 2023Article
- Traditional Herbal Remedies in the Management of Metabolic Disorders in Ethiopia: A Systematic Review of Ethnobotanical Studies and Pharmacological Activities.Evidence-based complementary and alternative medicine : eCAM · 2023Review
- Pharmacological evaluation of medicinal plants with antidiabetic activities in Ethiopia: A review.Metabolism open · 2022Review
- Prenatal developmental toxicity study of herbal tea ofToxicology reports · 2022Article
- Antidiabetic Activity of Mung Bean orEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Evaluation of in vivo Antidiabetic, Antidyslipidemic and in vitro Anti-Oxidant Activity of Extract and Solvent Fractions ofJournal of experimental pharmacology · 2022Article
- Antidiabetic Activity of Hot Tea Infusion of Leaves ofJournal of experimental pharmacology · 2022Article
- Comparative phytochemistry, antioxidant, antidiabetic, and anti-inflammatory activities of traditionally usedBiotechnologia · 2022Article
- Evaluation of Antidiabetic and Antihyperlipidemic Activity of 80% Methanolic Extract of the Root ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Evaluation of Anti-Diabetic and Anti-Hyperlipidemic Activities of Hydro-Alcoholic Crude Extract of the Shoot Tips ofJournal of experimental pharmacology · 2022Article
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- Methanolic Extract ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMoringa stenopetala has been used in traditional health systems to treat diabetes mellitus. The aim of this study was to investigate the antidiabetic activity of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin (STZ) induced diabetic rats.
methodsThe aqueous ethanol extract and n-butanol fraction of Moringa stenopetala leaves hydroalcoholic (500 mg/kg body weight) and metformin (150 mg/kg body weight) were administered to diabetic rats. Blood glucose, lipid profiles, liver and kidney function were examined after 14 days of experiment. Histopathological profile of the pancreas was also observed in diabetic rats at the end of study. An oral sucrose challenge test was also carried out to assess the post prandial effect of the extract.
resultsOral administration of the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves (500 mg/kg body weight) and metformin (150 mg/kg) significantly reduced blood glucose level (P<0.05), improved serum lipid profiles, liver enzymes and kidney functions in diabetic rats after 14 days. The extracts also improved damage of islet of Langerhan's in diabetic rats. The plant material reduced the post-prandial glucose level (P<0.001) at the dose of 750 mg/kg.
conclusionThese findings revealed that both the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves possess antihyperglycemic and antihyperlipidemic properties, and alleviate STZ-induced pancreatic damage in diabetic rats. The beneficial effects of plant material in inhibition of diabetes-induced complications are being investigated.
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