ArticleDrug and alcohol dependence2015
Addiction resistance: Definition, validation and association with mastery.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Revisiting the role of negative affect in alcohol use disorder: A longitudinal evaluation of Koob's allostatic model.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- Etiological Development of Alcohol Use and Dependence From Adolescence to Midlife in a Longitudinal Community Study of Twins.Alcohol, clinical & experimental research · 2026Article
- The collaborative study on the genetics of alcoholism: Sample and clinical data.Genes, brain, and behavior · 2023Review
- Exploration of Psychiatry Residents' Attitudes toward Patients with Substance Use Disorder, Bipolar Disorder and Schizophrenia in Saudi Arabia.Behavioral sciences (Basel, Switzerland) · 2023Article
- The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse.Development and psychopathology · 2022Article
- Modeling the association between and predictors of two constructs of resilience.Social psychiatry and psychiatric epidemiology · 2022Article
- Co-occurring Threats to Agency Among Female Sex Workers in Baltimore, Maryland.Journal of interpersonal violence · 2022Article
- Psychiatric Resilience and Alcohol Resistance: A Twin Study of Genetic Correlation and Sex Differences.Behavior genetics · 2021Article
- Potential causal effect of posttraumatic stress disorder on alcohol use disorder and alcohol consumption in individuals of European descent: A Mendelian Randomization Study.Alcoholism, clinical and experimental research · 2021Article
- Neurobiological mechanisms of early life adversity, blunted stress reactivity and risk for addiction.Neuropharmacology · 2021Review
- Longitudinal Examination of the Impact of Resilience and Stressful Life Events on Alcohol Use Disorder Outcomes.Substance use & misuse · 2021Article
- Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Addiction resistance to alcohol: What about heavy drinkers who avoid alcohol problems?Drug and alcohol dependence · 2019Article
- Purpose and mastery as predictors of perceived health and substance use problems.Journal of community psychology · 2019Article
- A classical twin study of PTSD symptoms and resilience: Evidence for a single spectrum of vulnerability to traumatic stress.Depression and anxiety · 2018Article
- The Role of Social, Familial, and Individual-Level Factors on Multiple Alcohol Use Outcomes During the First Year of University.Alcoholism, clinical and experimental research · 2017Article
- Compulsive methamphetamine taking in the presence of punishment is associated with increased oxytocin expression in the nucleus accumbens of rats.Scientific reports · 2017Article
- Risk and resistance perspectives in translation-oriented etiology research.Translational behavioral medicine · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundFor given levels of psychoactive substance use, symptoms of substance use disorder (SUD) can vary widely. The concept of addiction resistance (AR) seeks to capture this variation so we can understand its causes.
methodsIn a population-based twin sample, AR was defined as the deviation in the number of reported SUD criteria for a given substance from that predicted from the level of maximal consumption. Therefore, subjects with strong AR demonstrate few symptoms of SUD even at high levels of consumption. Twin modeling was performed by Mx.
resultsWe assessed AR for alcohol, nicotine and cannabis. Heritability was assessed at two occasions thereby correcting for measurement error and ranged from 35 to 52% with no evidence for shared environment. ARs for alcohol, nicotine and cannabis were relatively stable over time and were substantially predicted by parental history of SUD, early adversity, comorbidity with both internalizing and externalizing disorders, personality and especially by the trait of mastery.
conclusionsAR, which assesses individual variation in sensitivity to the development of SUD for a given level of drug exposure, may be a useful concept for addiction research. As applied to common psychoactive substances, AR is moderately heritable, relatively stable and predicted by family history, comorbidity and personality. The relationship with mastery is of particular interest in that it may reflect an ability to resist the progression of the addictive process into key life domains and to avoid loss of control of intake, even when consuming at high levels.
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