ArticleNeuroImage2015
Ventromedial prefrontal cortex drives hippocampal theta oscillations induced by mismatch computations.
Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characterizing hippocampal dynamics with MEG: A systematic review and evidence-based guidelines.Human brain mapping · 2019Pooled it
- Dissecting the Function of Hippocampal Oscillations in a Human Anxiety Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Trial
- Article
- Hippocampal patterns and associative memory: Distinct intracranial EEG temporal encoding patterns support memory.bioRxiv : the preprint server for biology · 2026Article
- Strong mnemonic prediction errors increase cognitive control, attention, and arousal.bioRxiv : the preprint server for biology · 2025Article
- Different frequencies of human scalp-recorded theta activity may index integration of activity in distinct recurrent cortico-subcortical mnemonic networks.Frontiers in behavioral neuroscience · 2025Review
- Theta Oscillations Support Prefrontal-hippocampal Interactions in Sequential Working Memory.Neuroscience bulletin · 2024Article
- Predictable and unpredictable deviance detection in the human hippocampus and amygdala.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- RDoC Framework Through the Lens of Predictive Processing: Focusing on Cognitive Systems Domain.Computational psychiatry (Cambridge, Mass.) · 2024Review
- Long-term, multi-event surprise correlates with enhanced autobiographical memory.Nature human behaviour · 2023Article
- Generalization of cognitive maps across space and time.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A Fluid Self-Concept: How the Brain Maintains Coherence and Positivity across an Interconnected Self-Concept While Incorporating Social Feedback.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Experiencing Surprise: The Temporal Dynamics of Its Impact on Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Has the concept of systems consolidation outlived its usefulness? Identification and evaluation of premises underlying systems consolidation.Faculty reviews · 2022Review
- Frontopolar theta oscillations link metacognition with prospective decision making.Nature communications · 2021Article
- Linking the Rapid Cascade of Visuo-Attentional Processes to Successful Memory Encoding.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- The Role of Hippocampal-Ventromedial Prefrontal Cortex Neural Dynamics in Building Mental Representations.Journal of cognitive neuroscience · 2021Article
- Effective connectivity during autobiographical memory search.Brain and behavior · 2020Article
- Role of the Hippocampus During Logical Reasoning and Belief Bias in Aging.Frontiers in aging neuroscience · 2020Article
- Conceptual Closure Elicited by Event Boundary Transitions Affects Commercial Communication Effectiveness.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Detecting environmental change is fundamental for adaptive behavior in an uncertain world. Previous work indicates the hippocampus supports the generation of novelty signals via implementation of a match-mismatch detector that signals when an incoming sensory input violates expectations based on past experience. While existing work has emphasized the particular contribution of the hippocampus, here we ask which other brain structures also contribute to match-mismatch detection. Furthermore, we leverage the fine-grained temporal resolution of magnetoencephalography (MEG) to investigate whether mismatch computations are spectrally confined to the theta range, based on the prominence of this range of oscillations in models of hippocampal function. By recording MEG activity while human subjects perform a task that incorporates conditions of match-mismatch novelty we show that mismatch signals are confined to the theta band and are expressed in both the hippocampus and ventromedial prefrontal cortex (vmPFC). Effective connectivity analyses (dynamic causal modeling) show that the hippocampus and vmPFC work as a functional circuit during mismatch detection. Surprisingly, our results suggest that the vmPFC drives the hippocampus during the generation and processing of mismatch signals. Our findings provide new evidence that the hippocampal-vmPFC circuit is engaged during novelty processing, which has implications for emerging theories regarding the role of vmPFC in memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.