Evidence map›Paper›PMID 26187292›Full record

SynthesisHepatology international2015

Performance of transient elastography assessing fibrosis of single hepatitis B virus infection: a systematic review and meta-analysis of a diagnostic test.

Xueying Xu, Yang Su, Ruixiang Song, Yang Sheng, Wensi Ai, Xiaofei Wu, Hongbo Liu

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Hepatology international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Review
  5. Autoimmune Hepatitis and Fibrosis.Journal of clinical medicine · 2023
    Review
  6. Article
  7. Diagnosis of liver fibrosis in patients with hepatitis B-related liver disease using ultrasound with wave-number domain attenuation coefficient.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020
    Article
  8. Review
  9. Article
  10. Article
  11. Performance of common imaging techniquesWorld journal of clinical cases · 2019
    Article
  12. Article
  13. Article
  14. Transient Elastography with Serum Hepatitis B Surface Antigen Enhances Liver Fibrosis Detection.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xueying XuDepartment of Epidemiology and Health Statistics, School of Public Health, China Medical University, Shenyang, 110001, People's Republic of China. bangjunjun@163.com.
Yang SuDepartment of Epidemiology and Health Statistics, School of Public Health, China Medical University, Shenyang, 110001, People's Republic of China. ocean107703@163.com.
Ruixiang SongDepartment of Urinary Surgery, Changhai Hospital, Shanghai, People's Republic of China. lori_win88@yahoo.com.cn.
Yang ShengDepartment of Epidemiology and Health Statistics, School of Public Health, China Medical University, Shenyang, 110001, People's Republic of China. ivorsy@163.com.
Wensi AiDepartment of Epidemiology and Health Statistics, School of Public Health, China Medical University, Shenyang, 110001, People's Republic of China. netaiwensi@126.com.
Xiaofei WuDepartment of Epidemiology and Health Statistics, School of Public Health, China Medical University, Shenyang, 110001, People's Republic of China. wuxiaofei1030@163.com.
Hongbo LiuDepartment of Epidemiology and Health Statistics, School of Public Health, China Medical University, Shenyang, 110001, People's Republic of China. hbliu@mail.cmu.edu.cn.
China Medical University · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTransient elastography has good diagnostic accuracy for predicting fibrosis and cirrhosis related to hepatitis B virus. However, the enrolled subjects in some studies have also included chronic hepatitis B patients with chronic hepatitis C coinfection or other etiologies of liver diseases. This might under- or overestimate the role of transient elastography in chronic hepatitis B patients.

methodsA systematic review was conducted on records in PubMed, EMBASE and the Cochrane Library electronic databases until 31 December 2013. We systematically assessed the effectiveness and accuracy of transient elastography for predicting the fibrosis and cirrhosis of the single hepatitis B virus. The questionnaire for quality assessment of diagnostic accuracy studies was used.

resultsIn this meta-analysis, out of 257 articles evaluated for eligibility, 165 satisfied the predetermined inclusion criteria for meta-analysis. Eventually, our final data set for the meta-analysis contained 19 studies. The areas under the summary receiver-operating characteristic curve for transient elastography of significant fibrosis and cirrhosis were 0.8225 and 0.9108, respectively. The pooled diagnostic odds ratios for transient elastography of significant fibrosis and cirrhosis were 11.19 (95 % CI 6.63-18.89) and 26.87 (95 % CI 17.88-40.38), respectively. In Europe, the areas of significant fibrosis and cirrhosis were 0.803 and 0.905; those in Asia were 0.871 and 0.914, respectively.

conclusionsBased on this meta-analysis we claim that liver stiffness measurement using transient elastography has good diagnostic accuracy for predicting single hepatitis B virus-related significant fibrosis and cirrhosis, especially in Asian populations.

Indexed as

Elasticity Imaging TechniquesHepatitis B, ChronicHumansLiverLiver CirrhosisROC CurveSeverity of Illness IndexFibrosisHepatitis B virusMeta-regressionSROCTransient elastography

Identifiers

PMID26187292
OpenAlexW879397303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.