ArticleBiology direct2015
Synthetic circuit designs for earth terraformation.
Article in Biology direct, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Synthetic horizontal gene transfer for ecosystem restoration.Biology direct · 2026Article
- Article
- Open problems in synthetic multicellularity.NPJ systems biology and applications · 2024Article
- Synthetic Ecosystems: From the Test Tube to the Biosphere.ACS synthetic biology · 2024Review
- Biocomputation: Moving Beyond Turing with Living Cellular Computers.Communications of the ACM · 2024Article
- Biodiversity as a firewall to engineered microbiomes for restoration and conservation.Royal Society open science · 2024Article
- Proposed solutions to anthropogenic climate change: A systematic literature review and a new way forward.Heliyon · 2023Article
- Prolonging genetic circuit stability through adaptive evolution of overlapping genes.Nucleic acids research · 2023Article
- Epistemology of synthetic biology: a new theoretical framework based on its potential objects and objectives.Frontiers in bioengineering and biotechnology · 2023Article
- Environmental Galenics: large-scale fortification of extant microbiomes with engineered bioremediation agents.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Ecological complexity and the biosphere: the next 30 years.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Network-level containment of single-species bioengineering.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Ecological firewalls for synthetic biology.iScience · 2022Article
- 15 years of microbial biotechnology: the time has come to think big-and act soon.Microbial biotechnology · 2022Article
- Predictive biology: modelling, understanding and harnessing microbial complexity.Nature reviews. Microbiology · 2020Review
- Synthetic soil crusts against green-desert transitions: a spatial model.Royal Society open science · 2020Article
- Soil Microbial Biogeography in a Changing World: Recent Advances and Future Perspectives.mSystems · 2020Review
- Synthetic Biology for Terraformation Lessons from Mars, Earth, and the Microbiome.Life (Basel, Switzerland) · 2020Article
- Toward Engineering Biosystems With Emergent Collective Functions.Frontiers in bioengineering and biotechnology · 2020Article
- Bottom-Up Approaches to Synthetic Cooperation in Microbial Communities.Life (Basel, Switzerland) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMounting evidence indicates that our planet might experience runaway effects associated to rising temperatures and ecosystem overexploitation, leading to catastrophic shifts on short time scales. Remediation scenarios capable of counterbalancing these effects involve geoengineering, sustainable practices and carbon sequestration, among others. None of these scenarios seems powerful enough to achieve the desired restoration of safe boundaries. PRESENTATION OF THE HYPOTHESIS: We hypothesize that synthetic organisms with the appropriate engineering design could be used to safely prevent declines in some stressed ecosystems and help improving carbon sequestration. Such schemes would include engineering mutualistic dependencies preventing undesired evolutionary processes. We hypothesize that some particular design principles introduce unescapable constraints to the engineered organisms that act as effective firewalls. TESTING THE HYPOTHESIS: Testing this designed organisms can be achieved by using controlled bioreactor models, with single and heterogeneous populations, and accurate computational models including different scales (from genetic constructs and metabolic pathways to population dynamics). IMPLICATIONS OF THE HYPOTHESIS: Our hypothesis heads towards a future anthropogenic action that should effectively act as Terraforming processes. It also implies a major challenge in the existing biosafety policies, since we suggest release of modified organisms as potentially necessary strategy for success.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.