Evidence map›Paper›PMID 26187243›Full record

ArticleJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2016

Model for end-stage liver disease predicts right ventricular failure in patients with left ventricular assist devices.

Gardner L Yost, Laura Coyle, Geetha Bhat, Antone J Tatooles

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Journal of Artificial Organs 2016: the year in review : Journal of Artificial Organs Editorial Committee.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2017
    Review
  7. The Predictive Value of the MELD Scores for In-Hospital Adverse Events in Normotensive Patients with Acute Pulmonary Embolism.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gardner L YostCenter for Heart Transplant and Assist Devices, Outpatient Pavilion, H&V Administration, Advocate Christ Medical Center, 6th Floor, 4440 West 95th Street, Oak Lawn, IL, 60453, USA. Gyost2@uic.edu.
Laura CoyleCenter for Heart Transplant and Assist Devices, Outpatient Pavilion, H&V Administration, Advocate Christ Medical Center, 6th Floor, 4440 West 95th Street, Oak Lawn, IL, 60453, USA.
Geetha BhatCenter for Heart Transplant and Assist Devices, Outpatient Pavilion, H&V Administration, Advocate Christ Medical Center, 6th Floor, 4440 West 95th Street, Oak Lawn, IL, 60453, USA. Geetha.Bhat@advocatehealth.com.
Antone J TatoolesDivision of Cardiothoracic Surgery, Advocate Christ Medical Center, Oak Lawn, IL, USA.
Advocate Christ Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High rates of right ventricular failure continue to affect postoperative outcomes in patients implanted with left ventricular assist devices (LVADs). Development of right ventricular failure and implantation with right ventricular assist devices is known to be associated with significantly increased mortality. The model for end-stage liver disease (MELD) score is an effective means of evaluating liver dysfunction. We investigated the prognostic utility of postoperative MELD on post-LVAD implantation outcomes. MELD scores, demographic data, and outcomes including length of stay, survival, and postoperative right ventricular failure were collected for 256 patients implanted with continuous flow LVADs. Regression and Kaplan-Meier analyses were used to investigate the relationship between MELD and all outcomes. Increased MELD score was found to be an independent predictor of both right heart failure and necessity for RVAD implantation (OR 1.097, CI 1.040-1.158, p = 0.001; OR 1.121, CI 1.015, p = 0.024, respectively). Patients with RV failure and who underwent RVAD implantation had reduced postoperative survival compared to patients with RV dysfunction (no RV failure = 651.4 ± 609.8 days, RV failure = 392.6 ± 444.8 days, RVAD = 89.3 ± 72.8 days; p < 0.001). In conclusion, MELD can be used to reliably predict postoperative right heart failure and the necessity for RVAD implantation. Those patients with RV failure and RVADs experience significantly increased postoperative mortality compared to those without RV dysfunction.

Indexed as

AdultAgedEnd Stage Liver DiseaseFemaleHeart-Assist DevicesHeart FailureHumansMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexTreatment OutcomeVentricular Dysfunction, RightCirculatory assist devices, LVAD, RVADLiverOutcomesStatistics, risk analysisVentricle, right

Identifiers

PMID26187243
OpenAlexW1011798846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.