ArticleThe Journal of allergy and clinical immunology2016
Ambient air pollution, lung function, and airway responsiveness in asthmatic children.
Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 191 citations in OpenAlex.
- Systematic review and meta-analysis of studies between short-term exposure to ambient carbon monoxide and non-accidental, cardiovascular, and respiratory mortality in China.Environmental science and pollution research international · 2022Pooled it
- Pooled it
- Effects of short-term exposure to air pollution on respiratory symptoms and lung function among patients with asthma.Medical gas research · 2026Article
- Review
- Impact of air pollution and asthma on school attendance and educational attainment: a scoping review.BMJ open respiratory research · 2025Article
- Associations of Early Life Ambient PMPediatric pulmonology · 2025Article
- Breathing Under Pressure? Air Pollution and Mortality in Pulmonary Hypertension.Annals of the American Thoracic Society · 2025Article
- Biomarkers of inflammation associated with radon exposure in the School Inner-City Asthma Study (SICAS).The Journal of allergy and clinical immunology · 2025Article
- Enhancer RNA transcription pinpoints functional genetic variants linked to asthma.Nature communications · 2025Article
- Comparative analysis of ambient, in-home, and personal exposures reveals associations between breathing zone pollutant levels and asthma exacerbations in high-risk children.Respiratory research · 2025Article
- Ambient air pollutant mixture and lung function among children in Fresno, California.PloS one · 2025Article
- Risk Factors for Acute Asthma Exacerbations in Adults With Mild Asthma.The journal of allergy and clinical immunology. In practice · 2024Article
- Clinical and inflammatory features of traffic-related diesel exposure in children with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Article
- Inhaled Corticosteroids Attenuate the Association of Fine Particulate Matter and Acute Asthma Events.American journal of respiratory and critical care medicine · 2024Article
- Article
- The association of air pollution in respiratory allergy: Its impact in an industrial city.The World Allergy Organization journal · 2024Article
- Long-term ozone exposure and lung function in middle childhood.Environmental research · 2024Article
- PMInternational journal of medical sciences · 2024Article
- The effect of air pollutants on COPD-hospitalized patients in Lanzhou, China (2015-2019).Frontiers in public health · 2024Article
- Ozone and childhood respiratory health: A primer for US pediatric providers and a call for a more protective standard.Pediatric pulmonology · 2023Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundAlthough ambient air pollution has been linked to reduced lung function in healthy children, longitudinal analyses of pollution effects in asthmatic patients are lacking.
objectiveWe sought to investigate pollution effects in a longitudinal asthma study and effect modification by controller medications.
methodsWe examined associations of lung function and methacholine responsiveness (PC20) with ozone, carbon monoxide (CO), nitrogen dioxide, and sulfur dioxide concentrations in 1003 asthmatic children participating in a 4-year clinical trial. We further investigated whether budesonide and nedocromil modified pollution effects. Daily pollutant concentrations were linked to ZIP/postal code of residence. Linear mixed models tested associations of within-subject pollutant concentrations with FEV1 and forced vital capacity (FVC) percent predicted, FEV1/FVC ratio, and PC20, adjusting for seasonality and confounders.
resultsSame-day and 1-week average CO concentrations were negatively associated with postbronchodilator percent predicted FEV1 (change per interquartile range, -0.33 [95% CI, -0.49 to -0.16] and -0.41 [95% CI, -0.62 to -0.21], respectively) and FVC (-0.19 [95% CI, -0.25 to -0.07] and -0.25 [95% CI, -0.43 to -0.07], respectively). Longer-term 4-month CO averages were negatively associated with prebronchodilator percent predicted FEV1 and FVC (-0.36 [95% CI, -0.62 to -0.10] and -0.21 [95% CI, -0.42 to -0.01], respectively). Four-month averaged CO and ozone concentrations were negatively associated with FEV1/FVC ratio (P < .05). Increased 4-month average nitrogen dioxide concentrations were associated with reduced postbronchodilator FEV1 and FVC percent predicted. Long-term exposures to sulfur dioxide were associated with reduced PC20 (percent change per interquartile range, -6% [95% CI, -11% to -1.5%]). Treatment augmented the negative short-term CO effect on PC20.
conclusionsAir pollution adversely influences lung function and PC20 in asthmatic children. Treatment with controller medications might not protect but rather worsens the effects of CO on PC20. This clinical trial design evaluates modification of pollution effects by treatment without confounding by indication.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.