Evidence map›Paper›PMID 26187121›Full record

Trial reportBMJ open2015

Refractory depression: mechanisms and evaluation of radically open dialectical behaviour therapy (RO-DBT) [REFRAMED]: protocol for randomised trial.

T R Lynch, B Whalley, R J Hempel, S Byford, P Clarke, S Clarke, D Kingdon, H O'Mahen, I T Russell, J Shearer and 4 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Psychological therapies for treatment-resistant depression in adults.The Cochrane database of systematic reviews · 2018
    Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. The Effect of Dialectic Behavioral Counseling on Depression, Anxiety, and Postpartum Hematocrit Level.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2021
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

T R LynchDepartment of Psychology, University of Southampton, Southampton, UK.
B WhalleyDepartment of Psychology, University of Plymouth, Plymouth, UK.
R J HempelDepartment of Psychology, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0001-9042-2319
S ByfordInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
P ClarkeInstitute for Social and Economic Research, University of Essex, Colchester, UK.
S ClarkeUniversity Department of Mental Health, Bournemouth University and Intensive Psychological Therapies Service, Dorset Health Care University NHS Foundation Trust, Poole, UK.
D KingdonDepartment of Medicine, University of Southampton, Southampton, UK.
H O'MahenMood Disorders Centre, University of Exeter, Exeter, UK.
I T RussellCollege of Medicine, Swansea University, Swansea, UK.
J ShearerPrimary Care and Public Health Sciences, King's College London, London, UK.
M StantonPsychology Services, Southern Health NHS Foundation Trust, Winchester, UK.
M SwalesSchool of Psychology, Bangor University, Bangor, UK.
A WatkinsCollege of Medicine, Swansea University, Swansea, UK.
B RemingtonDepartment of Psychology, University of Southampton, Southampton, UK.
University of Southampton · GBKing's College London · GBSwansea University · GBBangor University · GBDorset HealthCare University NHS Foundation Trust · GBSouthern Health NHS Foundation Trust · GBUniversity of Essex · GBUniversity of Exeter · GBUniversity of Plymouth · GB

Funding

Medical Research Council MC_PC_11006
6 · The paper itself

Abstract

introductionOnly 30-40% of depressed patients treated with medication achieve full remission. Studies that change medication or augment it by psychotherapy achieve only limited benefits, in part because current treatments are not designed for chronic and complex patients. Previous trials have excluded high-risk patients and those with comorbid personality disorder. Radically Open Dialectical Behaviour Therapy (RO-DBT) is a novel, transdiagnostic treatment for disorders of emotional over-control. The REFRAMED trial aims to evaluate the effectiveness and cost-effectiveness of RO-DBT for patients with treatment-resistant depression. METHODS AND ANALYSIS: REFRAMED is a multicentre randomised controlled trial, comparing 7 months of individual and group RO-DBT treatment with treatment as usual (TAU). Our primary outcome measure is depressive symptoms 12 months after randomisation. We shall estimate the cost-effectiveness of RO-DBT by cost per quality-adjusted life year. Causal analyses will explore the mechanisms by which RO-DBT is effective. ETHICS AND DISSEMINATION: The National Research Ethics Service (NRES) Committee South Central - Southampton A first granted ethical approval on 20 June 2011, reference number 11/SC/0146. TRIAL REGISTRATION NUMBER: ISRCTN85784627.

Indexed as

Behavior TherapyCost-Benefit AnalysisDepressionDrug ResistanceHumansQuality-Adjusted Life YearsResearch DesignRetreatmentRadically Open Dialectical Behaviour TherapyRefractory DepressionStudy Protocol

Identifiers

PMID26187121
PMCPMC4513446
OpenAlexW1935532468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.