ArticleAmerican journal of respiratory and critical care medicine2015
Quantitative Magnetic Resonance Imaging of Bronchopulmonary Dysplasia in the Neonatal Intensive Care Unit Environment.
Article in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Non-pharmacological strategies to obtain usable magnetic resonance images in non-sedated infants: Systematic review and meta-analysis.International journal of nursing studies · 2020Pooled it
- Assessing the feasibility of neonatal chest MRI for bronchopulmonary dysplasia using a standard 1.5-Tesla scanner.European radiology · 2026Article
- Follow-up of neonatal chronic respiratory disease: an update based on the current evidence.European journal of pediatrics · 2026Review
- Defining endotypes of bronchopulmonary dysplasia in preterm infants to improve precision-based therapies.JCI insight · 2025Review
- Lung MRI scoring reveals persistence of emphysema-like changes in lungs of infants born preterm at (pre)school age.ERJ open research · 2025Article
- Pulmonary MRI in Newborns and Children.Journal of magnetic resonance imaging : JMRI · 2025Review
- Patent Ductus Arteriosus and Lung Magnetic Resonance Imaging Phenotype in Moderate and Severe Bronchopulmonary Dysplasia-Pulmonary Hypertension.American journal of respiratory and critical care medicine · 2024Article
- Don't Forget the Kids!: Novel Pulmonary MRI and AI of Neonatal Lung Disease.Radiology. Artificial intelligence · 2023Article
- Automated MRI Lung Segmentation and 3D Morphologic Features for Quantification of Neonatal Lung Disease.Radiology. Artificial intelligence · 2023Article
- Magnetic Resonance Imaging-Based Evaluation of Anatomy and Outcome Prediction in Infants with Esophageal Atresia.Neonatology · 2023Observational
- Lung structure and function on MRI in preterm born school children with and without BPD: A feasibility study.Pediatric pulmonology · 2022Article
- Bronchopulmonary dysplasia from chest radiographs to magnetic resonance imaging and computed tomography: adding value.Pediatric radiology · 2022Review
- Tracheostomy prediction model in neonatal bronchopulmonary dysplasia via lung and airway MRI.Pediatric pulmonology · 2022Article
- Gravity-induced loss of aeration and atelectasis development in the preterm lung: a serial sonographic assessment.Journal of perinatology : official journal of the California Perinatal Association · 2022Observational
- Lung growth and pulmonary function after prematurity and bronchopulmonary dysplasia.Pediatric pulmonology · 2021Review
- Effects of neonatal lung abnormalities on parenchymal RJournal of magnetic resonance imaging : JMRI · 2021Article
- Modern pulmonary imaging of bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Commentary: Expert Opinion to "Imaging Bronchopulmonary Dysplasia-A Multimodality Update".Frontiers in medicine · 2021Article
- An Experimental Model of Bronchopulmonary Dysplasia Features Long-Term Retinal and Pulmonary Defects but Not Sustained Lung Inflammation.Frontiers in pediatrics · 2021Article
- Predicting Long-Term Respiratory Outcomes in Premature Infants: Is It Time to Move beyond Bronchopulmonary Dysplasia?Children (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
rationaleBronchopulmonary dysplasia (BPD) is a prevalent yet poorly characterized pulmonary complication of premature birth; the current definition is based solely on oxygen dependence at 36 weeks postmenstrual age without objective measurements of structural abnormalities across disease severity.
objectivesWe hypothesize that magnetic resonance imaging (MRI) can spatially resolve and quantify the structural abnormalities of the neonatal lung parenchyma associated with premature birth.
methodsUsing a unique, small-footprint, 1.5-T MRI scanner within our neonatal intensive care unit (NICU), diagnostic-quality MRIs using commercially available sequences (gradient echo and spin echo) were acquired during quiet breathing in six patients with BPD, six premature patients without diagnosed BPD, and six full-term NICU patients (gestational ages, 23-39 wk) at near term-equivalent age, without administration of sedation or intravenous contrast. Images were scored by a radiologist using a modified Ochiai score, and volumes of high- and low-signal intensity lung parenchyma were quantified by segmentation and threshold analysis. MEASUREMENTS AND MAIN
resultsSignal increases, putatively combinations of fibrosis, edema, and atelectasis, were present in all premature infants. Infants with diagnosed BPD had significantly greater volume of high-signal lung (mean ± SD, 26.1 ± 13.8%) compared with full-term infants (7.3 ± 8.2%; P = 0.020) and premature infants without BPD (8.2 ± 6.4%; P = 0.026). Signal decreases, presumably alveolar simplification, only appeared in the most severe BPD cases, although cystic appearance did increase with severity.
conclusionsPulmonary MRI reveals quantifiable, significant differences between patients with BPD, premature patients without BPD, and full-term control subjects. These methods could be implemented to individually phenotype disease, which may impact clinical care and predict future outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.