ArticleJournal of refractive surgery (Thorofare, N.J. : 1995)2015
Comparison of Corneal Epithelial Thickness Measurement Between Fourier-Domain OCT and Very High-Frequency Digital Ultrasound.
Article in Journal of refractive surgery (Thorofare, N.J. : 1995), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Detection of Keratoconus Using Ultrasound
Repeatability and Reproducibility of Carl Zeiss Meditec Cirrus HD OCT 5000, Optovue RTVue OCT, CSO MS-39 OCT and ArcScan Insight 100 Very High-frequency Digital Ultrasound and Comparison Between Devices
Who cites it
32 citing papers in PubMed.
- Ultrahigh-resolution anterior segment optical coherence tomography for analysis of corneal microarchitecture during wound healing.Acta ophthalmologica · 2019Trial
- Epithelial Thickness Changes After Descemet Membrane Endothelial Keratoplasty (DMEK): An Observational Study.Journal of clinical medicine · 2026Article
- Corneal epithelium is altered in keratoconus and forme fruste keratoconus.Scientific reports · 2025Article
- The role of corneal epithelial thickness map in detecting early keratoconus.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Determining the Relationship Between Regional Epithelial Thickness, Corneal Toricity, and Corneal Power in Normal Corneas.Journal of refractive surgery (Thorofare, N.J. : 1995) · 2025Article
- Repeatability of Corneal Epithelial Thickness Map Using Anterior-Segment Optical Coherence Tomography in Normal and Corneal Disease Patients.Korean journal of ophthalmology : KJO · 2024Article
- Article
- Blepharoptosis and corneal epithelial thickness alterations, is there any relation?BMC ophthalmology · 2024Article
- Transepithelial Photorefractive Keratectomy-Review.Vision (Basel, Switzerland) · 2024Review
- Corneal Epithelial Thickness Mapping: A Major Review.Journal of ophthalmology · 2024Review
- Descemet Membrane Endothelial Keratoplasty (DMEK) Reduces the Corneal Epithelial Thickness in Fuchs' Patients.Journal of clinical medicine · 2023Article
- Corneal Epithelial Thickness Changes After Topical Treatment of Dry Eye Disease in Primary Sjögren Syndrome.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Commentary: Usefulness of corneal epithelial thickness measurement.Indian journal of ophthalmology · 2022Article
- Corneal and corneal epithelial thickness distribution characteristics in healthy North Indian eyes using spectral domain optical coherence tomography.Indian journal of ophthalmology · 2022Observational
- Corneal Epithelial Mapping Characteristics in Normal Eyes Using Anterior Segment Spectral Domain Optical Coherence Tomography.Translational vision science & technology · 2022Article
- Age-Related Changes in Corneal Epithelial Thickness Measured with an Ultrasound Pachymeter.Clinical interventions in aging · 2022Article
- Corneal Epithelium Asymmetry in Children With Atopy: The Effect of Hand Dominance.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Evolution of corneal epithelial remodeling after myopic laserIndian journal of ophthalmology · 2021Article
- Current Developments in Corneal Topography and Tomography.Diagnostics (Basel, Switzerland) · 2021Review
- Corneal Epithelial Thickness Profile in Healthy Portuguese Children by High-Definition Optical Coherence Tomography.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeTo compare measurements of corneal epithelial thickness using optical coherence tomography (OCT) and very high-frequency digital ultrasound (VHFDU).
methodsRetrospective analysis of 189 virgin corneas and 175 post-laser refractive surgery (LRS) corneas that had corneal epithelial thickness measurement with RTVue Fourier-domain OCT (Optovue, Inc., Fremont, CA) (tear film included) and Artemis VHFDU (ArcScan Inc., Morrison, CO) (tear film excluded). Averages were calculated for the central 2-mm diameter zone and for two further concentric annuli of 1.5- and 0.5-mm width, each divided into eight sectors. Agreement was analyzed by mean difference (OCT - VHFDU), 95% limits of agreement (LoA) (1.96 standard deviation of the difference), and Bland-Altman analysis.
resultsIn virgin epithelium, mean central thickness was 53.4 ± 3.20 µm (range: 46 to 62 µm) with OCT and 54.1 ± 2.96 µm (range: 48 to 61 µm) with VHFDU; OCT measured thinnest in 70% with a mean difference of -0.71 µm (95% LoA of ± 3.94 µm, P < .001). In post-LRS epithelium, mean central thickness was 57.9 ± 6.08 µm (range: 42 to 77 µm) with OCT and 60.5 ± 6.47 µm (range: 42 to 79 µm) with VHFDU; OCT measured thinnest in 88%, with a mean difference of -2.48 µm (95% LoA of ± 5.33 µm, P < .001). A larger difference between methods was more common with thicker epithelium.
conclusionsCorneal epithelial thickness measurements using OCT were found to be slightly thinner than for VHFDU. In contrast to VHFDU, OCT measurement includes the tear film, so the true difference is probably approximately 4 µm more than reported. The difference was greatest inferiorly and higher for post-LRS eyes and in thicker epithelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.