Evidence map›Paper›PMID 26186300›Full record

ArticleThe Journal of clinical endocrinology and metabolism2015

Adiposity and Cardiometabolic Risk in Children With and Without Antipsychotic Drug Treatment.

Ginger E Nicol, Lisa de las Fuentes, Amy E Riek, Carlos Bernal-Mizrachi, Eric J Lenze, J Phillip Miller, Julia A Schweiger, Michael D Yingling, Vincent J Huang, David J Dixon and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ginger E NicolHealthy Mind Laboratory, Department of Psychiatry (G.E.N., E.J.L., J.A.S., M.D.Y., V.J.H., D.J.D.), Department of Internal Medicine, Division of Cardiology, Division of Biostatistics (L.d.l.F.), Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research (A.E.R., C.B.-M.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110; and Integrated Medical Science Department, First Sir Richard Doll Professor (C.H.H.), and Department of Clinical Biomedical Science (J.W.N.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
Lisa de las FuentesHealthy Mind Laboratory, Department of Psychiatry (G.E.N., E.J.L., J.A.S., M.D.Y., V.J.H., D.J.D.), Department of Internal Medicine, Division of Cardiology, Division of Biostatistics (L.d.l.F.), Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research (A.E.R., C.B.-M.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110; and Integrated Medical Science Department, First Sir Richard Doll Professor (C.H.H.), and Department of Clinical Biomedical Science (J.W.N.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
Amy E RiekHealthy Mind Laboratory, Department of Psychiatry (G.E.N., E.J.L., J.A.S., M.D.Y., V.J.H., D.J.D.), Department of Internal Medicine, Division of Cardiology, Division of Biostatistics (L.d.l.F.), Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research (A.E.R., C.B.-M.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110; and Integrated Medical Science Department, First Sir Richard Doll Professor (C.H.H.), and Department of Clinical Biomedical Science (J.W.N.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
Carlos Bernal-MizrachiHealthy Mind Laboratory, Department of Psychiatry (G.E.N., E.J.L., J.A.S., M.D.Y., V.J.H., D.J.D.), Department of Internal Medicine, Division of Cardiology, Division of Biostatistics (L.d.l.F.), Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research (A.E.R., C.B.-M.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110; and Integrated Medical Science Department, First Sir Richard Doll Professor (C.H.H.), and Department of Clinical Biomedical Science (J.W.N.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
Eric J LenzeHealthy Mind Laboratory, Department of Psychiatry (G.E.N., E.J.L., J.A.S., M.D.Y., V.J.H., D.J.D.), Department of Internal Medicine, Division of Cardiology, Division of Biostatistics (L.d.l.F.), Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research (A.E.R., C.B.-M.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110; and Integrated Medical Science Department, First Sir Richard Doll Professor (C.H.H.), and Department of Clinical Biomedical Science (J.W.N.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
J Phillip MillerHealthy Mind Laboratory, Department of Psychiatry (G.E.N., E.J.L., J.A.S., M.D.Y., V.J.H., D.J.D.), Department of Internal Medicine, Division of Cardiology, Division of Biostatistics (L.d.l.F.), Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research (A.E.R., C.B.-M.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110; and Integrated Medical Science Department, First Sir Richard Doll Professor (C.H.H.), and Department of Clinical Biomedical Science (J.W.N.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
Julia A SchweigerHealthy Mind Laboratory, Department of Psychiatry (G.E.N., E.J.L., J.A.S., M.D.Y., V.J.H., D.J.D.), Department of Internal Medicine, Division of Cardiology, Division of Biostatistics (L.d.l.F.), Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research (A.E.R., C.B.-M.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110; and Integrated Medical Science Department, First Sir Richard Doll Professor (C.H.H.), and Department of Clinical Biomedical Science (J.W.N.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
Michael D YinglingHealthy Mind Laboratory, Department of Psychiatry (G.E.N., E.J.L., J.A.S., M.D.Y., V.J.H., D.J.D.), Department of Internal Medicine, Division of Cardiology, Division of Biostatistics (L.d.l.F.), Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research (A.E.R., C.B.-M.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110; and Integrated Medical Science Department, First Sir Richard Doll Professor (C.H.H.), and Department of Clinical Biomedical Science (J.W.N.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
Vincent J HuangHealthy Mind Laboratory, Department of Psychiatry (G.E.N., E.J.L., J.A.S., M.D.Y., V.J.H., D.J.D.), Department of Internal Medicine, Division of Cardiology, Division of Biostatistics (L.d.l.F.), Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research (A.E.R., C.B.-M.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110; and Integrated Medical Science Department, First Sir Richard Doll Professor (C.H.H.), and Department of Clinical Biomedical Science (J.W.N.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
David J DixonHealthy Mind Laboratory, Department of Psychiatry (G.E.N., E.J.L., J.A.S., M.D.Y., V.J.H., D.J.D.), Department of Internal Medicine, Division of Cardiology, Division of Biostatistics (L.d.l.F.), Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research (A.E.R., C.B.-M.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110; and Integrated Medical Science Department, First Sir Richard Doll Professor (C.H.H.), and Department of Clinical Biomedical Science (J.W.N.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
Charles H HennekensHealthy Mind Laboratory, Department of Psychiatry (G.E.N., E.J.L., J.A.S., M.D.Y., V.J.H., D.J.D.), Department of Internal Medicine, Division of Cardiology, Division of Biostatistics (L.d.l.F.), Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research (A.E.R., C.B.-M.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110; and Integrated Medical Science Department, First Sir Richard Doll Professor (C.H.H.), and Department of Clinical Biomedical Science (J.W.N.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
John W NewcomerHealthy Mind Laboratory, Department of Psychiatry (G.E.N., E.J.L., J.A.S., M.D.Y., V.J.H., D.J.D.), Department of Internal Medicine, Division of Cardiology, Division of Biostatistics (L.d.l.F.), Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research (A.E.R., C.B.-M.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110; and Integrated Medical Science Department, First Sir Richard Doll Professor (C.H.H.), and Department of Clinical Biomedical Science (J.W.N.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
Iowa Diabetes and Endocrinology Research Center · USFlorida Atlantic University · USWashington University in St. Louis · US

Funding

Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Irfan J Lodhi · 2013 to 2026
$27.1M
Washington University Institute of Clinical and Translational SciencesKL2TR000450 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$8.8M
INTERDISCIPLINARY RESEARCH CAREERS IN WOMEN'S HEALTHK12HD001459 · NICHD · WASHINGTON UNIVERSITY · PI SEMENKOVICH, CLAY F. · 2000 to 2014
$6.9M
VITAMIN D DEFICIENCY, INSULIN RESISTANCE AND CARDIOVASCULAR DISEASER01HL094818 · NHLBI · WASHINGTON UNIVERSITY · PI Carlos Bernal-Mizrachi · 2010 to 2026
$6.3M
Measurement of Cardiometabolic Risk in Antipsychotic-Treated ChildrenK23MH092435 · NIMH · WASHINGTON UNIVERSITY · PI NICOL, GINGER E · 2011 to 2015
$816k
ULTRASOUND SYSTEM FOR CARDIOVASCULAR PHENOTYPE STUDIES IN HUMANSS10RR024532 · NCRR · WASHINGTON UNIVERSITY · PI DAVILA-ROMAN, VICTOR G. · 2009 to 2009
$237k
NCATS NIH HHS KL2 TR000450NCATS NIH HHS UL1 TR000448NCRR NIH HHS S10 RR024532NCRR NIH HHS S10RR024532NCRR NIH HHS UL1 RR024992NCRR NIH HHS UL1RR024992NHLBI NIH HHS R01 HL094818NHLBI NIH HHS R01HL094818NICHD NIH HHS K12 HD001459NICHD NIH HHS K12HD001459NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30DK056341NIMH NIH HHS K23 MH092435NIMH NIH HHS K23MH092435
6 · The paper itself

Abstract

contextPediatric obesity is common, particularly in children treated with antipsychotic medications. Antipsychotic exposure can increase cardiometabolic risk by increasing adiposity, and possibly via other adiposity-independent pathways.

objectiveThe objectives were to characterize relationships of adiposity with intrahepatic triglyceride (IHTG) content and carotid intima media thickness (CIMT) in children with and without antipsychotic drug treatment, and to explore whether vitamin D alters any effects in these relationships.

designThis was a cross-sectional case-control study.

settingThe setting was an academic medical center. PATIENTS OR OTHER

participantsParticipants were 44 children (ages, 6-19 y): 25 cases treated with antipsychotic and other psychotropic drug therapies and 19 untreated controls, frequency-matched on age, gender, and body mass index.

main outcome measuresMain outcome measures were dual-energy x-ray absorptiometry percentage body fat (DEXA %fat), IHTG measured by magnetic resonance spectroscopy, and CIMT measured by ultrasonography. Fasting blood glucose, insulin, lipids, C-reactive protein, and liver enzymes were also evaluated.

resultsThere were no significant differences between cases and controls on measures of IHTG, CIMT, or DEXA %fat. In combined crude and adjusted analyses, DEXA %fat predicted IHTG (R(2) = 0.30) but not CIMT. Low levels of vitamin D were associated with larger effects of DEXA %fat on IHTG.

conclusionIn treated and untreated children alike, adiposity is a significant predictor of liver fat content. This relationship was altered by low vitamin D level. These results suggest a modifiable pathway to hepatic steatosis. Further research is needed to test the hypothesis that children with high adiposity and low vitamin D have particularly increased risks for the development of fatty liver.

Indexed as

AdiposityAdolescentAntipsychotic AgentsCardiovascular DiseasesCarotid Intima-Media ThicknessChildCross-Sectional StudiesFatty LiverFemaleHumansMaleRiskVitamin DYoung AdultAntipsychotic AgentsVitamin D

Identifiers

PMID26186300
PMCPMC4570158
OpenAlexW2116729284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.