Evidence map›Paper›PMID 26186217›Full record

ArticlePloS one2015

Adolescent Loneliness and the Interaction between the Serotonin Transporter Gene (5-HTTLPR) and Parental Support: A Replication Study.

Annette W M Spithoven, Patricia Bijttebier, Wim Van Den Noortgate, Hilde Colpin, Karine Verschueren, Karla Van Leeuwen, Stephan Claes, Luc Goossens

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In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Annette W M SpithovenDepartment of School Psychology and Child and Adolescent Development, KU Leuven, Leuven, Belgium.
Patricia BijttebierDepartment of School Psychology and Child and Adolescent Development, KU Leuven, Leuven, Belgium.
Wim Van Den NoortgateDepartment of Methodology of Educational Sciences, KU Leuven, Leuven, Belgium.
Hilde ColpinDepartment of School Psychology and Child and Adolescent Development, KU Leuven, Leuven, Belgium.
Karine VerschuerenDepartment of School Psychology and Child and Adolescent Development, KU Leuven, Leuven, Belgium.
Karla Van LeeuwenDepartment of Parenting and Special Education, KU Leuven, Leuven, Belgium.
Stephan ClaesDepartment of Neuroscience, KU Leuven, Leuven, Belgium.
Luc GoossensDepartment of School Psychology and Child and Adolescent Development, KU Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene-by-environment interaction (GxEs) studies have gained popularity over the last decade, but the robustness of such observed interactions has been questioned. The current study contributes to this debate by replicating the only study on the interaction between the serotonin transporter gene (5-HTTLPR) and perceived parental support on adolescents' peer-related loneliness. A total of 1,111 adolescents (51% boys) with an average age of 13.70 years (SD = 0.93) participated and three annual waves of data were collected. At baseline, adolescent-reported parental support and peer-related loneliness were assessed and genetic information was collected. Assessment of peer-related loneliness was repeated at Waves 2 and 3. Using a cohort-sequential design, a Latent Growth Curve Model was estimated. Overall, a slight increase of loneliness over time was found. However, the development of loneliness over time was found to be different for boys and girls: girls' levels of loneliness increased over time, whereas boys' levels of loneliness decreased. Parental support was inversely related to baseline levels of loneliness, but unrelated to change of loneliness over time. We were unable to replicate the main effect of 5-HTTLPR or the 5-HTTLPR x Support interaction effect. In the Discussion, we examine the implications of our non-replication.

Indexed as

ParentsAdolescentFemaleHumansLonelinessMaleModels, GeneticReproducibility of ResultsSerotonin Plasma Membrane Transport ProteinsTime FactorsSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, human

Identifiers

PMID26186217
PMCPMC4505935

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.