ArticleCell2015
Primacy of Flexor Locomotor Pattern Revealed by Ancestral Reversion of Motor Neuron Identity.
Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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Who cites it
44 citing papers in PubMed.
- Spatial and network principles behind neural generation of locomotion.Nature communications · 2026Article
- Hoxa9 compensates for the absence of Hoxc9 in suppressing limb-type motor neurons in sharks.Zoological letters · 2026Article
- V2b Neurons Act via Multiple Targets to Produce in Phase Inhibition during Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization.eLife · 2024Article
- Molecular and Cellular Mechanisms of Motor Circuit Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- A computational study of how an α- to γ-motoneurone collateral can mitigate velocity-dependent stretch reflexes during voluntary movement.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- An alpha- to gamma-motoneurone collateral can mitigate velocity-dependent stretch reflexes during voluntary movement: A computational study.bioRxiv : the preprint server for biology · 2024Article
- Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization.bioRxiv : the preprint server for biology · 2024Article
- Spinal maps of motoneuron activity during human locomotion: neuromechanical considerations.Frontiers in physiology · 2024Review
- Complexity of modular neuromuscular control increases and variability decreases during human locomotor development.Communications biology · 2022Article
- Little skate genome provides insights into genetic programs essential for limb-based locomotion.eLife · 2022Article
- Left-Right Locomotor Coordination in Human Neonates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Roles of Mono- and Bi-articular Muscles in Human Limbs: Two-joint Link Model and Applications.Integrative organismal biology (Oxford, England) · 2022Review
- Establishing the Molecular and Functional Diversity of Spinal Motoneurons.Advances in neurobiology · 2022Article
- Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons.Nature neuroscience · 2021Article
- Single Cell Transcriptomic Analysis of Spinal Dmrt3 Neurons in Zebrafish and Mouse Identifies Distinct Subtypes and Reveal Novel Subpopulations Within the dI6 Domain.Frontiers in cellular neuroscience · 2021Article
- Distinct locomotor precursors in newborn babies.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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- Development of Locomotor-Related Movements in Early Infancy.Frontiers in cellular neuroscience · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Spinal circuits can generate locomotor output in the absence of sensory or descending input, but the principles of locomotor circuit organization remain unclear. We sought insight into these principles by considering the elaboration of locomotor circuits across evolution. The identity of limb-innervating motor neurons was reverted to a state resembling that of motor neurons that direct undulatory swimming in primitive aquatic vertebrates, permitting assessment of the role of motor neuron identity in determining locomotor pattern. Two-photon imaging was coupled with spike inference to measure locomotor firing in hundreds of motor neurons in isolated mouse spinal cords. In wild-type preparations, we observed sequential recruitment of motor neurons innervating flexor muscles controlling progressively more distal joints. Strikingly, after reversion of motor neuron identity, virtually all firing patterns became distinctly flexor like. Our findings show that motor neuron identity directs locomotor circuit wiring and indicate the evolutionary primacy of flexor pattern generation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.