Evidence map›Paper›PMID 26186135›Full record

ArticleEnvironmental research2015

Arsenic exposure and hepatitis E virus infection during pregnancy.

Christopher D Heaney, Brittany Kmush, Ana Navas-Acien, Kevin Francesconi, Walter Gössler, Kerry Schulze, DeLisa Fairweather, Sucheta Mehra, Kenrad E Nelson, Sabra L Klein and 8 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03930017 (Arsenic and Immune Response to Influenza Vaccination in Pregnant Women and Newborns), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03930017 completednot on this mapstarted 2018, after this paper: background citation

Arsenic and Immune Response to Influenza Vaccination in Pregnant Women and Newborns

TypeobservationalSponsorJohns Hopkins Bloomberg School of Public HealthRan2018 to 2020Enrolled784ConditionsArsenic--Toxicology, Immunologic Disorders Complicating Pregnancy, Vaccine Response Impaired, Micronutrient DeficiencyArmsSeasonal influenza vaccine - VAXIGRIP TETRA influenza vaccine (quadrivalent, split virion, inactivated)
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020
    Pooled it
  3. Role of viral hepatitis in pregnancy and its triggering mechanism.Journal of translational internal medicine · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. The interplay between environmental exposures and COVID-19 risks in the health of children.Environmental health : a global access science source · 2021
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Epidemiology of Genotype 1 and 2 Hepatitis E Virus Infections.Cold Spring Harbor perspectives in medicine · 2019
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Christopher D HeaneyDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: cheaney1@jhu.edu.
Brittany KmushDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Ana Navas-AcienDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Kevin FrancesconiInstitute of Chemistry-Analytical Chemistry, Graz University, Austria.
Walter GösslerInstitute of Chemistry-Analytical Chemistry, Graz University, Austria.
Kerry SchulzeDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
DeLisa FairweatherDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Sucheta MehraDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
Kenrad E NelsonDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Sabra L KleinDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Wei LiDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, USA.
Hasmot AliThe JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
Saijuddin ShaikhThe JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
Rebecca D MerrillDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
Lee WuDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
Keith P WestDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
Parul ChristianDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
Alain B LabriqueDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.

Funding

PILOT STUDY--ACID FOG, AN EXPERIMENTAL MODELP30ES003819 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI GROOPMAN, JOHN D · 1985 to 2012
$22.6M
Arsenic Exposure, Genetic Determinants and Diabetes Risk in a Family StudyR01ES021367 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI NAVAS-ACIEN, ANA, VAIDYA, DHANANJAY MADHUKAR · 2012 to 2015
$2.4M
Sex Differences in Complement during Myocarditis/DCMR01HL111938 · NHLBI · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2012 to 2015
$1.6M
Endocrine disruptors effect on inflammatory heart diseaseR21ES024414 · NIEHS · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2014 to 2015
$440k
Non-Invasive Zoonotic Pathogen Exposure & Outcome BiomarkersK01OH010193 · OH · JOHNS HOPKINS UNIVERSITY · PI HEANEY, CHRISTOPHER D · 2012 to 2014
$324k
Incidence and Natural History of Hepatitis E Virus in Pregnant Bangladeshi WomenR56AI068813 · NIAID · JOHNS HOPKINS UNIVERSITY · PI LABRIQUE, ALAIN BERNARD · 2010 to 2010
$255k
NHLBI NIH HHS R01 HL111938NHLBI NIH HHS R01HL111938NIAID NIH HHS R56 AI068813NIAID NIH HHS R56 AI068813-01A2NIEHS NIH HHS P30 ES003819NIEHS NIH HHS P30ES003819NIEHS NIH HHS R01 ES021367NIEHS NIH HHS R01ES021367NIEHS NIH HHS R21 ES024414NIOSH CDC HHS 1K01OH010193-01A1NIOSH CDC HHS K01 OH010193
6 · The paper itself

Abstract

backgroundArsenic has immunomodulatory properties and may have the potential to alter susceptibility to infection in humans.

objectivesWe aimed to assess the relation of arsenic exposure during pregnancy with immune function and hepatitis E virus (HEV) infection, defined as seroconversion during pregnancy and postpartum.

methodsWe assessed IgG seroconversion to HEV between 1st and 3rd trimester (TM) and 3 months postpartum (PP) among 1100 pregnancies in a multiple micronutrient supplementation trial in rural Bangladesh. Forty women seroconverted to HEV and were matched with 40 non-seroconverting women (controls) by age, parity and intervention. We assessed urinary inorganic arsenic plus methylated species (∑As) (µg/L) at 1st and 3rd TM and plasma cytokines (pg/mL) at 1st and 3rd TM and 3 months PP.

resultsHEV seroconverters' urinary ∑As was elevated throughout pregnancy. Non-seroconverters' urinary ∑As was similar to HEV seroconverters at 1st TM but declined at 3rd TM. The adjusted odds ratio (95% confidence interval) of HEV seroconversion was 2.17 (1.07, 4.39) per interquartile range (IQR) increase in average-pregnancy urinary ∑As. Increased urinary ∑As was associated with increased concentrations of IL-2 during the 1st and 3rd TM and 3 months PP among HEV seroconverters but not non-seroconverters.

conclusionsThe relation of urinary arsenic during pregnancy with incident HEV seroconversion and with IL-2 levels among HEV-seroconverting pregnant women suggests arsenic exposure during pregnancy may enhance susceptibility to HEV infection.

Indexed as

AdolescentAdultAntibodies, ViralArsenicBangladeshCase-Control StudiesCytokinesDisease SusceptibilityEnvironmental ExposureEnvironmental PollutantsFemaleHepatitis EHepatitis E virusHumansImmunoglobulin GPregnancyAntibodies, ViralArsenicCytokinesEnvironmental PollutantsImmunoglobulin GArsenicCytokinesHepatitis E virusImmunotoxicityInfectionPregnancy

Identifiers

PMID26186135
PMCPMC4609253

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.