ArticleHealth promotion and chronic disease prevention in Canada : research, policy and practice2015
Impact of pre-pregnancy diabetes mellitus on congenital anomalies, Canada, 2002-2012.
Article in Health promotion and chronic disease prevention in Canada : research, policy and practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Risks of specific congenital anomalies in offspring of women with diabetes: A systematic review and meta-analysis of population-based studies including over 80 million births.PLoS medicine · 2022Pooled it
- Evaluating the Performance of Traditional Pharmacoepidemiologic and Machine Learning Models to Predict Pregnancies at Risk of Major Congenital Malformations.Birth defects research · 2026Article
- SARS-CoV-2 Infection and Rates of Neonatal Congenital Anomalies.JAMA network open · 2026Article
- A Population-Based Study of U.S. Trends in Selected Congenital Anomalies (2016-2023) and Socio-Demographic Disparities: A CDC WONDER Analysis.Children (Basel, Switzerland) · 2026Article
- Prenatal Opioid Use Disorder and the Risk of Congenital Anomalies in Offspring: A Population-Based Study.Birth defects research · 2025Article
- Maternal periconception hyperglycemia, preconception diabetes, and risk of major congenital malformations in offspring.Human reproduction (Oxford, England) · 2024Article
- Maternal Metabolic Status and Orofacial Cleft Risk: A Case-Control Study in Thailand.International dental journal · 2024Article
- Importance of Prenatal Diagnosis of Ileal Atresia in Gestational Diabetes Cases.The American journal of case reports · 2024Article
- Epigenetic implications in maternal diabetes and metabolic syndrome-associated risk of orofacial clefts.Birth defects research · 2023Review
- Trend of pregnancy outcomes in type 1 diabetes compared to control women: a register-based analysis in 1996-2018.Frontiers in endocrinology · 2023Article
- Trends in maternal characteristics and perinatal outcomes among Japanese pregnant women with type 1 and type 2 diabetes from 1982 to 2020.Journal of diabetes investigation · 2022Article
- Prevalence of gestational diabetes and its association with stillbirth, preterm birth, macrosomia, abortion and cesarean delivery: a national prevalence study of 11 provinces in Iran.Journal of preventive medicine and hygiene · 2021Article
- Predictors of congenital anomalies among newborns in Arsi zone public hospitals, Southeast Ethiopia: a case-control study.Italian journal of pediatrics · 2021Article
- Periconception glycemic control and congenital anomalies in women with pregestational diabetes.BMJ open diabetes research & care · 2021Article
- Association of Improved Periconception Hemoglobin A1c With Pregnancy Outcomes in Women With Diabetes.JAMA network open · 2020Article
- Association of Maternal Prepregnancy Diabetes and Gestational Diabetes Mellitus With Congenital Anomalies of the Newborn.Diabetes care · 2020Article
- Maternal risk factors for the VACTERL association: A EUROCAT case-control study.Birth defects research · 2020Article
- A Systematic Review and Meta-Analysis of Diabetes During Pregnancy and Congenital Genitourinary Abnormalities.Kidney international reports · 2020Article
- Maternal Obesity and Diabetes Mellitus as Risk Factors for Congenital Heart Disease in the Offspring.Journal of the American Heart Association · 2020Review
- Intergenerational Effects of Health Issues Among Women of Childbearing Age: a Review of the Recent Literature.Current nutrition reports · 2018Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo examine the impact of pre-pregnancy diabetes mellitus (DM) on the population birth prevalence of congenital anomalies in Canada.
methodsWe carried out a population-based study of all women who delivered in Canadian hospitals (except those in the province of Quebec) between April 2002 and March 2013 and their live-born infants with a birth weight of 500 grams or more and/or a gestational age of 22 weeks or more. Pre-pregnancy type 1 or type 2 DM was identified using ICD-10 diagnostic codes. The association between DM and all congenital anomalies as well as specific congenital anomaly categories was estimated using adjusted odds ratios; the impact was calculated as a population attributable risk percent (PAR%).
resultsThere were 118,892 infants with a congenital anomaly among 2,839,680 live births (41.9 per 1000). While the prevalence of any congenital anomaly declined from 50.7 per 1000 live births in 2002/03 to 41.5 per 1000 in 2012/13, the corresponding PAR% for a congenital anomaly related to pre-pregnancy DM rose from 0.6% (95% confidence interval [CI]: 0.4-0.8) to 1.2% (95% CI: 0.9-1.4). Specifically, the PAR% for congenital cardiovascular defects increased from 2.3% (95% CI: 1.7-2.9) to 4.2% (95% CI: 3.5-4.9) and for gastrointestinal defects from 0.8% (95% CI: 0.2-1.9) to 1.4% (95% CI: 0.7-2.6) over the study period.
conclusionAlthough there has been a relative decline in the prevalence of congenital anomalies in Canada, the proportion of congenital anomalies due to maternal pre-pregnancy DM has increased. Enhancement of preconception care initiatives for women with DM is recommended.
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