ArticlePloS one2015
Tuberculous Meningitis in Children and Adults: A 10-Year Retrospective Comparative Analysis.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Microbiological diagnosis and mortality of tuberculosis meningitis: Systematic review and meta-analysis.PloS one · 2023Pooled it
- Tuberculosis related disability: a systematic review and meta-analysis.BMC medicine · 2021Pooled it
- Ventriculoperitoneal shunt insertion in human immunodeficiency virus infected adults: a systematic review and meta-analysis.BMC neurology · 2020Pooled it
- Infliximab in a Child With Relapsing Tuberculous Meningoencephalitis: A Case Report and Literature Review.The Pediatric infectious disease journal · 2026Review
- Incidence of cranial and ophthalmic nerve palsy and associated risk factors in tuberculous meningitis: A systematic review and meta-regression analysis.IBRO neuroscience reports · 2026Review
- Drug-induced liver injury as a strong independent predictor of in-hospital mortality in tuberculous meningitis: potential age-related effect modification suggested in a large lifespan cohort.Frontiers in medicine · 2026Article
- Global burden of multidrug-resistant tuberculosis in children and adolescents.Pediatric research · 2025Article
- Tuberculous Meningitis Across the Lifespan.The Journal of infectious diseases · 2025Review
- The Urban-Rural Divide in Neurocritical Care in Low-Income and Middle-Income Countries.Neurocritical care · 2024Article
- Occurrence and determinants of seizures and their impact on tuberculous meningitis: a prospective evaluation.Acta neurologica Belgica · 2024Observational
- Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics.Biomedicines · 2023Review
- Clinical Profile of Pediatric Tuberculosis in a Tertiary Hospital in Northeast India: A Retrospective Analysis.Cureus · 2023Article
- Treatment outcomes and risk factors of death in childhood tuberculous meningitis in Kandahar, Afghanistan: a prospective observational cohort study.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022Observational
- Fatal tuberculous meningitis in an infant presenting with seizures in the UK.BMJ case reports · 2021Article
- Risk factors for poor outcome in childhood tuberculous meningitis.Scientific reports · 2021Article
- Uncommon presentation of craniospinal tuberculosis.Qatar medical journal · 2021Article
- Infection in the Developing Brain: The Role of Unique Systemic Immune Vulnerabilities.Frontiers in neurology · 2021Review
- Neutrophil-Mediated Immunopathology and Matrix Metalloproteinases in Central Nervous System - Tuberculosis.Frontiers in immunology · 2021Review
- Treatment Outcomes in Adult Tuberculous Meningitis: A Systematic Review and Meta-analysis.Open forum infectious diseases · 2020Article
- Performance of immune-based and microbiological tests in children with tuberculosis meningitis in Europe: a multicentre Paediatric Tuberculosis Network European Trials Group (ptbnet) study.The European respiratory journal · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTuberculous meningitis (TBM) is the most lethal form of Mycobacterium tuberculosis infection, which has a high rate of neurological complications and sequelae.
objectivesOur study offers a real-world infectious disease clinic perspective, being thus representative for the clinical environment of developing countries.
methodsWe performed a retrospective analysis of the 127 adult and 77 pediatric cases diagnosed with TBM in the Infectious Disease Hospital of the School of Medicine of Iasi, Romania between 2004-2013.
resultsDefinite diagnosis of TBM was established in 31% of children but in only 20% of adults (p = 0.043). A contact with an individual with pulmonary tuberculosis was documented in 30% of children vs. 13% of adults (p = 0.0007). Coma occurred in 19% of patients (similar in children and adults); other consciousness abnormalities were seen in 27% of children and in 72% of adults (p = 0.000001). Cranial nerve palsies occurred prior to therapy in 9% of cases (12% vs 7% of children and adults, respectively, p>0.05), and developed 2-7 days after treatment initiation in 10% (12 vs 9%). CSF cultures were positive for M. tuberculosis in 24% of patients (31% vs. 20%, p>0.05). Overall mortality was 7.35%, similar for children and adults. Yet, permanent neurological sequelae, which were seen in 23% of patients occurred significantly more frequent in children vs. adults (36% vs. 14%, respectively, p = 0.0121). In conclusion, our retrospective analysis on a significant number of cases of TBM identified striking differences between children and adults: while children were in an earlier stage at the admission, they associated a higher frequency of neurological sequelae and miliary pattern, and they were more likely to have normal CSF protein levels and positive cultures of CSF.
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