ArticleJournal of cardiovascular development and disease
Vascular Calcification and Stone Disease: A New Look towards the Mechanism.
Article in Journal of cardiovascular development and disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Vascular calcification on the risk of kidney stone: a meta-analysis.Renal failure · 2023Pooled it
- Genetically predicted Circulating inflammatory proteins mediate the association between plasma lipidome and kidney stones: A Mendelian randomization study.Urolithiasis · 2025Article
- A cross-sectional study of the association between plant-based diet indices and kidney stones among Iranian adults.Scientific reports · 2025Article
- Kidney stone and risk of cardiovascular diseases: a cross-sectional study in the southeast of Iran.BMC nephrology · 2025Article
- Vascular calcification in kidney stone formers: the impact of age and stone composition.Urolithiasis · 2024Article
- Ablation of TRPC3 disrupts CaScientific reports · 2023Article
- Association Between Kidney Stone and Dental Calculus in a Saudi Population: A Cross-Sectional Study.Cureus · 2023Article
- Kidney stone disease and abdominal aortic calcification: possible relationship and clinical significance.International urology and nephrology · 2022Article
- Association between aortic calcification and the presence of kidney stones: calcium oxalate calculi in focus.International urology and nephrology · 2022Article
- Collagen fibrils and cell nuclei are entrapped within Randall's plaques but not in CaOx matrix overgrowth: A microscopic inquiry into Randall's plaque stone pathogenesis.Anatomical record (Hoboken, N.J. : 2007) · 2022Article
- Urinary metabolic profile and stone composition in kidney stone formers with and without heart disease.Journal of nephrology · 2022Article
- The Pulp Stones: Morphological Analysis in Scanning Electron Microscopy and Spectroscopic Chemical Quantification.Medicina (Kaunas, Lithuania) · 2021Article
- The relationship between vascular calcifications and urolithiasis in a large, multiethnic patient population.Urolithiasis · 2021Article
- Mechanism of action of SNF472, a novel calcification inhibitor to treat vascular calcification and calciphylaxis.British journal of pharmacology · 2020Article
- Relationship between Kidney Stone Disease and Arterial Stiffness in a Taiwanese Population.Journal of clinical medicine · 2020Article
- Risk of Kidney Stones: Influence of Dietary Factors, Dietary Patterns, and Vegetarian-Vegan Diets.Nutrients · 2020Review
- A comprehensive analysis of sialolith proteins and the clinical implications.Clinical proteomics · 2020Article
- Novel bisphosphonate compound FYB-931 preferentially inhibits aortic calcification in vitamin D3-treated rats.Journal of bone and mineral metabolism · 2019Article
- Confounding risk factors and preventative measures driving nephrolithiasis global makeup.World journal of nephrology · 2018Review
- Vitamin D in Vascular Calcification: A Double-Edged Sword?Nutrients · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Calcium phosphate (CaP) crystals are formed in pathological calcification as well as during stone formation. Although there are several theories as to how these crystals can develop through the combined interactions of biochemical and biophysical factors, the exact mechanism of such mineralization is largely unknown. Based on the published scientific literature, we found that common factors can link the initial stages of stone formation and calcification in anatomically distal tissues and organs. For example, changes to the spatiotemporal conditions of the fluid flow in tubular structures may provide initial condition(s) for CaP crystal generation needed for stone formation. Additionally, recent evidence has provided a meaningful association between the active participation of proteins and transcription factors found in the bone forming (ossification) mechanism that are also involved in the early stages of kidney stone formation and arterial calcification. Our review will focus on three topics of discussion (physiological influences-calcium and phosphate concentration-and similarities to ossification, or bone formation) that may elucidate some commonality in the mechanisms of stone formation and calcification, and pave the way towards opening new avenues for further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.