Evidence map›Paper›PMID 26185649›Full record

ArticleClinical case reports2015

Identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing.

Tohru Daikoku, Yukari Oyama, Misako Yajima, Tsuyoshi Sekizuka, Makoto Kuroda, Yuka Shimada, Kazuhiko Takehara, Naoko Miwa, Tomoko Okuda, Tetsutaro Sata and 1 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Tohru DaikokuDepartment of Virology, University of Toyama Toyama, 930-0194, Japan.
Yukari OyamaDepartment of Virology, University of Toyama Toyama, 930-0194, Japan.
Misako YajimaDepartment of Virology, University of Toyama Toyama, 930-0194, Japan.
Tsuyoshi SekizukaPathogen Genomics Center, National Institute of Infectious Diseases 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Makoto KurodaPathogen Genomics Center, National Institute of Infectious Diseases 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Yuka ShimadaDepartment of Dermatology, Kanazawa University Graduate School of Medical Science Kanazawa, Ishikawa, 920-8640, Japan.
Kazuhiko TakeharaDepartment of Dermatology, Kanazawa University Graduate School of Medical Science Kanazawa, Ishikawa, 920-8640, Japan.
Naoko MiwaDepartment of Gynecology and Obstetrics, University of Toyama Toyama, 930-0194, Japan ; Department of Obstetrics and Gynecology, Shakaihoken Takaoka Hospital Takaoka, Toyama, 933-0115, Japan.
Tomoko OkudaDepartment of Virology, University of Toyama Toyama, 930-0194, Japan.
Tetsutaro SataDepartment of Virology, Toyama Institute of Health Toyama, 939-0363, Japan.
Kimiyasu ShirakiDepartment of Virology, University of Toyama Toyama, 930-0194, Japan.
University of Toyama · JPKanazawa University · JPNational Institute of Infectious Diseases · JPToyama Institute of Health · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpes simplex virus 2 caused a genital ulcer, and a secondary herpetic whitlow appeared during acyclovir therapy. The secondary and recurrent whitlow isolates were acyclovir-resistant and temperature-sensitive in contrast to a genital isolate. We identified the ribonucleotide reductase mutation responsible for temperature-sensitivity by deep-sequencing analysis.

Indexed as

Herpes simplex virushigh-throughput DNA sequencingreactivationribonucleotide reductasetemperature-sensitive (Ts)thymidine kinase deficient

Identifiers

PMID26185649
PMCPMC4498863
OpenAlexW2019024518

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.