Evidence map›Paper›PMID 26185621›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2015

Pediatric Herpes Simplex Virus Encephalitis Complicated by N-Methyl-D-aspartate Receptor Antibody Encephalitis.

Alasdair Bamford, Belinda H A Crowe, Yael Hacohen, Jean-Pierre Lin, Antonia Clarke, Gareth Tudor-Williams, Vanessa Sancho-Shimizu, Angela Vincent, Ming Lim, Sunil P Pullaperuma

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

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  10. Herpes Simplex Encephalitis: an Update.Current infectious disease reports · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Alasdair BamfordDepartment of Paediatric Infectious Diseases ; Section of Paediatrics, Imperial College, London, United Kingdom.
Belinda H A CrowePaediatric Neurodisability Service, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Yael HacohenNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom.
Jean-Pierre LinChildren's Neurosciences, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Antonia ClarkeDepartment of Paediatric Neurology, St George's Hospital, St George's Hospital NHS Trust, London, United Kingdom.
Gareth Tudor-WilliamsDepartment of Paediatric Infectious Diseases ; Section of Paediatrics, Imperial College, London, United Kingdom.
Vanessa Sancho-ShimizuSection of Paediatrics, Imperial College, London, United Kingdom.
Angela VincentNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom.
Ming LimNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom ; Children's Neurosciences, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Sunil P PullaperumaPaediatric Neurodisability Service, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Imperial College London · GBJohn Radcliffe Hospital · GBSt Mary's Hospital · GBEvelina London Children's Healthcare · GBSt George's Hospital · GBUniversity of Oxford · GB

Funding

MRF_ C0483
6 · The paper itself

Abstract

N-methyl-D-aspartate receptor antibodies (NMDAR-Abs) can contribute to neurological relapse after herpes simplex virus encephalitis (HSE). We describe a child with NMDAR-Ab encephalitis after HSE, which was recognized and treated early. We discuss the case in the context of existing reports, and we propose a modified immunotherapy strategy to minimize risk of viral reactivation.

Indexed as

AcyclovirAnti-N-Methyl-D-Aspartate Receptor EncephalitisAntiviral AgentsAutoantibodiesClonidineDiazepamEncephalitis, Herpes SimplexEncephalomalaciaFemaleFeverHumansImmunocompromised HostImmunosuppression TherapyInfantLeukoencephalopathiesMovement DisordersAcyclovirAntiviral AgentsAutoantibodiesClonidineDiazepamPhenobarbitalPhenytoinReceptors, N-Methyl-D-AspartateTrihexyphenidylValproic AcidencephalitisHSVNMDARpediatricplasmapheresis

Identifiers

PMID26185621
PMCPMC4501512
OpenAlexW2171026723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.