ReviewNeuropsychiatric disease and treatment2015
The influence of atypical antipsychotic drugs on sexual function.
Review in Neuropsychiatric disease and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Prevalence of sexual dysfunction in Chinese patients with schizophrenia: a systematic review and meta-analysis.Sexual medicine · 2024Review
- The association of hypogonadism with depression and its treatments.Frontiers in endocrinology · 2023Review
- Sexual knowledge of Queensland forensic mental health patients: A cross-sectional quantitative study.Frontiers in psychiatry · 2023Article
- Antipsychotic Drug-Mediated Adverse Effects on Rat Testicles May Be Caused by Altered Redox and Hormonal Homeostasis.International journal of molecular sciences · 2022Article
- The sexuality and sexual experiences of forensic mental health patients: An integrative review of the literature.Frontiers in psychiatry · 2022Review
- A community pharmacist's intervention in antipsychotic drug-induced sexual dysfunction in a patient with schizophrenia.Clinical case reports · 2021Article
- Management Strategies for Antipsychotic-Related Sexual Dysfunction: A Clinical Approach.Journal of clinical medicine · 2021Review
- Sexual Dysfunction in Chronically Medicated Male Inpatients With Schizophrenia: Prevalence, Risk Factors, Clinical Manifestations, and Response to Sexual Arousal.Frontiers in psychiatry · 2021Article
- Sexual dysfunction in Chinese rural patients with schizophrenia.BMC psychiatry · 2019Article
- Management of sexual adverse effects induced by atypical antipsychotic medicationJournal of psychiatry & neuroscience : JPN · 2019Article
- Brain Cortical and Hippocampal Dopamine: A New Mechanistic Approach forEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Effects of long-term treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens.International urology and nephrology · 2017Article
- Safety, tolerability, and risks associated with first- and second-generation antipsychotics: a state-of-the-art clinical review.Therapeutics and clinical risk management · 2017Review
- Lack of tolerable treatment options for patients with schizophrenia.Neuropsychiatric disease and treatment · 2015Article
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human sexuality is contingent upon many biological and psychological factors. Such factors include sexual drive (libido), physiological arousal (lubrication/erection), orgasm, and ejaculation, as well as maintaining normal menstrual cycle. The assessment of sexual dysfunction can be difficult due to the intimate nature of the problem and patients' unwillingness to discuss it. Also, the problem of dysfunction is often overlooked by doctors. Atypical antipsychotic treatment is a key component of mental disorders' treatment algorithms recommended by the National Institute of Health and Clinical Excellence, the American Psychiatric Association, and the British Society for Psychopharmacology. The relationship between atypical antipsychotic drugs and sexual dysfunction is mediated in part by antipsychotic blockade of pituitary dopamine D2 receptors increasing prolactin secretion, although direct correlations have not been established between raised prolactin levels and clinical symptoms. Variety of mechanisms are likely to contribute to antipsychotic-related sexual dysfunction, including hyperprolactinemia, sedation, and antagonism of a number of neurotransmitter receptors (α-adrenergic, dopaminergic, histaminic, and muscarinic). Maintaining normal sexual function in people treated for mental disorders can affect their quality of life, mood, self-esteem, attitude toward taking medication, and compliance during therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.