Evidence map›Paper›PMID 26185209›Full record

ArticleCirculation research2015

Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative.

Peipei Ping, Åsa B Gustafsson, Don M Bers, Lothar A Blatter, Hua Cai, Arshad Jahangir, Daniel Kelly, Deborah Muoio, Brian O'Rourke, Peter Rabinovitch and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. MMP9 inhibition increases autophagic flux in chronic heart failure.American journal of physiology. Heart and circulatory physiology · 2020
    Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Peipei PingFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
Åsa B GustafssonFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
Don M BersFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
Lothar A BlatterFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
Hua CaiFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
Arshad JahangirFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
Daniel KellyFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
Deborah MuoioFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
Brian O'RourkeFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
Peter RabinovitchFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
Natalia TrayanovaFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
Jennifer Van EykFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
James N WeissFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
Renee WongFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.).
Lisa Schwartz LongacreFrom the Departments of Physiology and Medicine, UCLA David Geffen School of Medicine (P.P., H.C., J.N.W.); Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla (Å.B.G.); Department of Pharmacology, UC Davis, Davis, CA (D.M.B.); Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL (L.A.B.); Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research, Aurora Health Care, Milwaukee, WI (A.J.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL (D.K.); Department of Medicine, Duke University, Durham, NC (D.M.); Department of Medicine, Division of Cardiology (B.O.R.), Department of Biomedical Engineering (N.T.), and Department of Medicine, Division of Cardiology (J.V.E.), The Johns Hopkins University School of Medicine, Baltimore, MD (B.O'R., N.T., J.V.E.); Department of Pathology, University of Washington, Seattle (P.R.); and Heart Failure and Arrhythmia Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W., L.S.L.). schwartzlongal@mail.nih.gov.

Funding

SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI RABINOVITCH, PETER S · 1985 to 2021
$29.6M
Program AdministrationP01HL080101 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2006 to 2015
$23.4M
REGULATION OF FATTY ACID OXIDATION DURING CARDIAC GROWTHR01HL058493 · NHLBI · WASHINGTON UNIVERSITY · PI KELLY, DANIEL PATRICK · 1998 to 2024
$10.6M
Phospholemman and Na-Pump Function in Cardiac MyocytesR01HL081562 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2005 to 2018
$5.3M
Angiotensin II Uncoupling of Enos in HypertensionR01HL077440 · NHLBI · UNIVERSITY OF CHICAGO · PI CAI, HUA LINDA · 2005 to 2019
$4.8M
NOXs, eNOS Uncoupling and Diabetic AtherogenesisR01HL088975 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2010 to 2019
$4.5M
IONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGR01HL030077 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BERS, DONALD M · 1986 to 2018
$3.8M
A Genomic/Metabolomic Strategy to Characterize Cardiac Mitochondrial DysfunctionR01HL101189 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KELLY, DANIEL PATRICK, MUOIO, DEBORAH M · 2010 to 2013
$2.9M
MItochondrial Dysfunction in Cardiac Hypertrophy and FailureR01HL101235 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BERS, DONALD M, BLATTER, LOTHAR A · 2010 to 2013
$2.8M
Mitochondrial pathways in NO induced cardioprotectionR01HL101228 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA, PING, PEIPEI · 2010 to 2013
$2.6M
Cardiomyocyte mitochondria and mtROS in cardiac aging, hypertrophy and failureR01HL101186 · NHLBI · UNIVERSITY OF WASHINGTON · PI RABINOVITCH, PETER S · 2010 to 2013
$2.5M
Endothelium-Myocardium Interaction in Netrin-1 Induced CardioprotectionR01HL119968 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2013 to 2017
$2.5M
NHLBI NIH HHS P01 HL080101NHLBI NIH HHS R01 HL030077NHLBI NIH HHS R01 HL058493NHLBI NIH HHS R01 HL077440NHLBI NIH HHS R01 HL088975NHLBI NIH HHS R01 HL101186NHLBI NIH HHS R01-HL101186NHLBI NIH HHS R01 HL101189NHLBI NIH HHS R01-HL101189NHLBI NIH HHS R01 HL101217NHLBI NIH HHS R01-HL101217NHLBI NIH HHS R01 HL101228NHLBI NIH HHS R01-HL101228NHLBI NIH HHS R01 HL101235NHLBI NIH HHS R01-HL101235NHLBI NIH HHS R01 HL101240NHLBI NIH HHS R01-HL101240NHLBI NIH HHS R01 HL108701NHLBI NIH HHS R01 HL117385NHLBI NIH HHS R01 HL119968NIA NIH HHS P01 AG001751
6 · The paper itself

Abstract

Mitochondrial biology is the sum of diverse phenomena from molecular profiles to physiological functions. A mechanistic understanding of mitochondria in disease development, and hence the future prospect of clinical translations, relies on a systems-level integration of expertise from multiple fields of investigation. Upon the successful conclusion of a recent National Institutes of Health, National Heart, Lung, and Blood Institute initiative on integrative mitochondrial biology in cardiovascular diseases, we reflect on the accomplishments made possible by this unique interdisciplinary collaboration effort and exciting new fronts on the study of these remarkable organelles.

Indexed as

Cooperative BehaviorForecastingGovernment ProgramsHeart DiseasesHumansInterdisciplinary CommunicationInventionsMedical Informatics ComputingMitochondria, HeartModels, CardiovascularMyocytes, CardiacNational Heart, Lung, and Blood Institute (U.S.)Program EvaluationSystems BiologyTherapies, InvestigationalTranslational Research, Biomedicalcardiovascular diseasecell deathheart diseasesmitochondriaNational Heart, Lung, and Blood Institute (U.S.)

Identifiers

PMID26185209
PMCPMC4535701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.