Evidence map›Paper›PMID 26185193›Full record

ArticleJournal of the National Cancer Institute2015

Effects of Antiretroviral Therapy on Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Transmission Among HIV-Infected Zambian Children.

Landon N Olp, Veenu Minhas, Clement Gondwe, Chipepo Kankasa, Janet Wojcicki, Charles Mitchell, John T West, Charles Wood

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Institute, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Epidemiology of Kaposi's sarcoma in Zambia, 2007 - 2014.Malawi medical journal : the journal of Medical Association of Malawi · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. HIV-associated malignancies in children.Current opinion in HIV and AIDS · 2017
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Landon N OlpNebraska Center for Virology and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE (LNO, VM, JTW); Department of Pediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia (CG, CK); Department of Pediatrics and Department of Nutrition, University of California, San Francisco, CA (JW); Department of Pediatric Immunology/Infectious Diseases, University of Miami School of Medicine, Miami, FL (CM); Nebraska Center for Virology and School of Biological Sciences (CW) and Department of Biochemistry (CW), University of Nebraska-Lincoln, Lincoln, NE. Current affiliation: Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha NE (VM).
Veenu MinhasNebraska Center for Virology and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE (LNO, VM, JTW); Department of Pediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia (CG, CK); Department of Pediatrics and Department of Nutrition, University of California, San Francisco, CA (JW); Department of Pediatric Immunology/Infectious Diseases, University of Miami School of Medicine, Miami, FL (CM); Nebraska Center for Virology and School of Biological Sciences (CW) and Department of Biochemistry (CW), University of Nebraska-Lincoln, Lincoln, NE. Current affiliation: Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha NE (VM).
Clement GondweNebraska Center for Virology and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE (LNO, VM, JTW); Department of Pediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia (CG, CK); Department of Pediatrics and Department of Nutrition, University of California, San Francisco, CA (JW); Department of Pediatric Immunology/Infectious Diseases, University of Miami School of Medicine, Miami, FL (CM); Nebraska Center for Virology and School of Biological Sciences (CW) and Department of Biochemistry (CW), University of Nebraska-Lincoln, Lincoln, NE. Current affiliation: Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha NE (VM).
Chipepo KankasaNebraska Center for Virology and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE (LNO, VM, JTW); Department of Pediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia (CG, CK); Department of Pediatrics and Department of Nutrition, University of California, San Francisco, CA (JW); Department of Pediatric Immunology/Infectious Diseases, University of Miami School of Medicine, Miami, FL (CM); Nebraska Center for Virology and School of Biological Sciences (CW) and Department of Biochemistry (CW), University of Nebraska-Lincoln, Lincoln, NE. Current affiliation: Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha NE (VM).
Janet WojcickiNebraska Center for Virology and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE (LNO, VM, JTW); Department of Pediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia (CG, CK); Department of Pediatrics and Department of Nutrition, University of California, San Francisco, CA (JW); Department of Pediatric Immunology/Infectious Diseases, University of Miami School of Medicine, Miami, FL (CM); Nebraska Center for Virology and School of Biological Sciences (CW) and Department of Biochemistry (CW), University of Nebraska-Lincoln, Lincoln, NE. Current affiliation: Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha NE (VM).
Charles MitchellNebraska Center for Virology and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE (LNO, VM, JTW); Department of Pediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia (CG, CK); Department of Pediatrics and Department of Nutrition, University of California, San Francisco, CA (JW); Department of Pediatric Immunology/Infectious Diseases, University of Miami School of Medicine, Miami, FL (CM); Nebraska Center for Virology and School of Biological Sciences (CW) and Department of Biochemistry (CW), University of Nebraska-Lincoln, Lincoln, NE. Current affiliation: Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha NE (VM).
John T WestNebraska Center for Virology and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE (LNO, VM, JTW); Department of Pediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia (CG, CK); Department of Pediatrics and Department of Nutrition, University of California, San Francisco, CA (JW); Department of Pediatric Immunology/Infectious Diseases, University of Miami School of Medicine, Miami, FL (CM); Nebraska Center for Virology and School of Biological Sciences (CW) and Department of Biochemistry (CW), University of Nebraska-Lincoln, Lincoln, NE. Current affiliation: Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha NE (VM).
Charles WoodNebraska Center for Virology and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE (LNO, VM, JTW); Department of Pediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia (CG, CK); Department of Pediatrics and Department of Nutrition, University of California, San Francisco, CA (JW); Department of Pediatric Immunology/Infectious Diseases, University of Miami School of Medicine, Miami, FL (CM); Nebraska Center for Virology and School of Biological Sciences (CW) and Department of Biochemistry (CW), University of Nebraska-Lincoln, Lincoln, NE. Current affiliation: Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha NE (VM). cwood1@unl.edu.
University Teaching Hospital · ZMUniversity of California, San Francisco · USUniversity of Miami · USUniversity of Nebraska–Lincoln · US

Funding

KAPOSIS SARCOMA AND HUMAN HERPESVIRUS IN AFRICAR01CA075903 · NCI · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 1998 to 2015
$11.1M
Nebraska Center for VirologyP30GM103509 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2012 to 2014
$3.3M
Research Training in Comparative Viral PathogenesisT32AI060547 · NIAID · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2004 to 2013
$2.5M
FIC NIH HHS D43 TW01492NCI NIH HHS R01 CA75903NIAID NIH HHS T32 AI060547NIGMS NIH HHS P30 GM103509
6 · The paper itself

Abstract

backgroundThe risk of Kaposi's sarcoma-associated herpesvirus (KSHV) acquisition among children is increased by HIV infection. Antiretroviral therapy (ART) was recently made widely available to HIV-infected children in Zambia. However, the impact of early ART on KSHV transmission to HIV-infected children is unknown.

methodsWe enrolled and followed a cohort of 287 HIV-exposed, KSHV-negative children under 12 months of age from Lusaka, Zambia, to identify KSHV seroconversion events. Potential factors associated with KSHV infection-with an emphasis on HIV, ART, and immunological measures-were assessed through structured questionnaires and blood analyses. Incidence rate, Kaplan-Meier, and multivariable Cox regression models were used to assess differences in time to event (KSHV seroconversion) between groups. All statistical tests were two-sided.

resultsDuring follow-up, 151 (52.6%) children underwent KSHV seroconversion. Based on 3552 months of follow-up, we observed similar KSHV incidence rates between HIV-infected and uninfected children. Among HIV-infected children, ART-naïve children had statistically significantly increased risk of KSHV acquisition (adjusted hazard ratio [AHR] = 5.04, 95% confidence interval [CI] = 2.36 to 10.80, P < .001). Time-updated CD4(+) T-cell percentage was also statistically significantly associated with risk of KSHV acquisition (AHR = 0.82, 95% CI = 0.74 to 0.92, P < .001), such that each 5% increase of CD4(+) T-cells represented an 18% decrease in risk of acquiring KSHV.

conclusionsOur data suggest that early ART and prevention of immune suppression reduce the risk of KSHV acquisition among HIV-infected children in an area where both viruses are highly endemic. This study highlights the importance of programs in Africa to provide children with ART immediately after HIV infection is diagnosed.

Indexed as

Antibodies, ViralAnti-Retroviral AgentsCD4 Lymphocyte CountChildChild, PreschoolFemaleFollow-Up StudiesHerpesviridae InfectionsHerpesvirus 8, HumanHIV InfectionsHumansIncidenceKaplan-Meier EstimateMaleProportional Hazards ModelsRiskAntibodies, ViralAnti-Retroviral Agents

Identifiers

PMID26185193
PMCPMC6090874
OpenAlexW1758139789

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.