Evidence map›Paper›PMID 26185103›Full record

Observational studyBMC surgery2015

The TICAP-Study (titanium clips for appendicular stump closure): A prospective multicentre observational study on appendicular stump closure with an innovative titanium clip.

Alexander Rickert, Colin M Krüger, Norbert Runkel, Andreas Kuthe, Jörg Köninger, Boris Jansen-Winkeln, Carsten N Gutt, Daniel R Marcus, Brian Hoey, Moritz N Wente and 1 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01734837 (Prospective Multicenter Observational Study), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01734837 completednot on this map

Prospective Multicenter Observational Study (Registry) on the Aesculap DS Titanium Ligation Clips for Appendiceal Stump Closure.

TypeobservationalSponsorAesculap AGRan2011 to 2013Enrolled390ConditionsAppendicitisArmsDS-Ligature Clip
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Laparoscopic Appendectomy versus Open Surgery.JSLS : Journal of the Society of Laparoendoscopic Surgeons
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexander RickertDepartment of Surgery, University medical centre Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167, Mannheim, Germany.
Colin M KrügerDepartment of Surgery, Vivantes-Humboldt Klinikum, D-13509, Berlin, Germany.
Norbert RunkelDepartment of Surgery, Schwarzwald-Baar-Klinikum, D-78052, Villingen-Schwenningen, Germany.
Andreas KutheDepartment of Surgery, DRK Krankenhaus Clementinenhaus, D-30161, Hannover, Germany.
Jörg KöningerDepartment of Surgery, Katharinenhospital, D-70174, Stuttgart, Germany.
Boris Jansen-WinkelnDepartment of Surgery, University medical centre Mainz, D-55131, Mainz, Germany.
Carsten N GuttDepartment of Surgery, Klinikum Memmingen, D-87700, Memmingen, Germany.
Daniel R MarcusMarina del Rey Hospital, Marina del Rey, California, CA, 90292, USA.
Brian HoeyGeneral Surgery, St. Luke's university hospital, Bethlehem, PA, 18015, USA.
Moritz N WenteMedical Scientific Affairs, Aesculap AG, D-78532, Tuttlingen, Germany.
Peter KienleDepartment of Surgery, University medical centre Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167, Mannheim, Germany. peter.kienle@umm.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the effectiveness and safety of the DS Titanium Ligation Clip for appendicular stump closure in laparoscopic appendectomy.

methodsOverall, 502 patients undergoing laparoscopic appendectomy were recruited for this observational multicentre study in nine study centres between October 2011 and July 2013. The clip was finally applied in 390 patients. Primary outcome variables were feasibility of the clip, intra-abdominal surgical site (abscesses, stump leakages) and superficial wound infections. Patients were followed 30 days after surgery.

resultsThe clip was applicable in nearly 80 % of patients. Reasons for not applying the clip were mainly an inflamed caecum or a too large diameter of the appendix base. Superficial wound infections were found in nine (2.31 %), intra-abdominal abscesses in five (1.28 %), appendicular stump leak in one (0.26 %), and other adverse events in 22 (5.64 %) patients. In total, 12 (3.08 %) patients were re-admitted to hospital for treatment. Seven re-admissions were surgery-related; ten (2.56 %) patients had to be re-operated. One patient died during the course of the study due to persisting peritonitis (mortality 0.26 %).

conclusionsThe results suggest that the DS Titanium Ligation Clip is a safe and effective option in securing the appendicular stump in laparoscopic appendectomy. The complication rates found with the use of the DS-Clip are comparable to the rates in the literature when other methods are used.

trial registrationNCT01734837 .

Indexed as

AdultAgedAged, 80 and overAppendectomyAppendicitisFeasibility StudiesFemaleFollow-Up StudiesHumansLaparoscopyMaleMiddle AgedPostoperative ComplicationsProspective StudiesTitaniumTreatment OutcomeTitanium

Identifiers

PMID26185103
PMCPMC4504402

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.