Evidence map›Paper›PMID 26185018›Full record

ArticleGenome biology2015

Epigenome data release: a participant-centered approach to privacy protection.

Stephanie O M Dyke, Warren A Cheung, Yann Joly, Ole Ammerpohl, Pavlo Lutsik, Mark A Rothstein, Maxime Caron, Stephan Busche, Guillaume Bourque, Lars Rönnblom and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. EpiATLAS - a reference for human epigenomic research.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Stephanie O M DykeCentre of Genomics and Policy, Department of Human Genetics, McGill University, Montreal, QC, H3A 0G1, Canada. Stephanie.Dyke@mcgill.ca.
Warren A CheungDepartment of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal, QC, H3A 0G1, Canada.
Yann JolyCentre of Genomics and Policy, Department of Human Genetics, McGill University, Montreal, QC, H3A 0G1, Canada.
Ole AmmerpohlInstitute of Human Genetics, University Hospital Schleswig-Holstein, Campus Kiel & Christian-Albrechts-University Kiel, 24105, Kiel, Germany.
Pavlo LutsikSaarland University, 66123, Saarbrücken, Germany.
Mark A RothsteinInstitute for Bioethics, Health Policy and Law, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Maxime CaronDepartment of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal, QC, H3A 0G1, Canada.
Stephan BuscheDepartment of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal, QC, H3A 0G1, Canada.
Guillaume BourqueDepartment of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal, QC, H3A 0G1, Canada.
Lars RönnblomDepartment of Medical Sciences, Science for Life Laboratory, Uppsala University, SE-751 85, Uppsala, Sweden.
Paul FlicekEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Stephan BeckMedical Genomics, UCL Cancer Institute, University College London, London, WC1E 6BT, UK.
Martin HirstCentre for High-Throughput Biology, University of British Columbia and Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, V5Z 4S6, Canada.
Henk StunnenbergDepartment of Molecular Biology, RIMLS, Faculty of Science, Radboud University, 6500 HB, Nijmegen, The Netherlands.
Reiner SiebertInstitute of Human Genetics, University Hospital Schleswig-Holstein, Campus Kiel & Christian-Albrechts-University Kiel, 24105, Kiel, Germany.
Jörn WalterSaarland University, 66123, Saarbrücken, Germany.
Tomi PastinenDepartment of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal, QC, H3A 0G1, Canada. Tomi.Pastinen@mcgill.ca.

Funding

Canadian Institutes of Health Research EP1-120608Canadian Institutes of Health Research EP2-120609NIGMS NIH HHS Y01 GM001114
6 · The paper itself

Abstract

Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA methylation data at one base-pair resolution. We examine how such data can be made open-access while balancing appropriate interpretation and genomic privacy. We propose guidelines for data release that both reduce ambiguity in the interpretation of open-access data and limit immediate access to genetic variation data that are made available through controlled access.

Indexed as

EpigenomicsGenetic PrivacyData AnonymizationDNA MethylationEpigenesis, GeneticGenetic VariationHigh-Throughput Nucleotide SequencingHumansSequence Analysis, DNA

Identifiers

PMID26185018
PMCPMC4504083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.