Evidence map›Paper›PMID 26184984›Full record

ArticleJournal of the American Society for Mass Spectrometry2015

Differentiating Fragmentation Pathways of Cholesterol by Two-Dimensional Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.

Maria A van Agthoven, Mark P Barrow, Lionel Chiron, Marie-Aude Coutouly, David Kilgour, Christopher A Wootton, Juan Wei, Andrew Soulby, Marc-André Delsuc, Christian Rolando and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Enhancing the Sensitivity of Mass Spectrometry Imaging through Spatial Signal Averaging.Journal of the American Society for Mass Spectrometry · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. The Phytochemical Profile of the Petroleum Ether Extract ofInternational journal of molecular sciences · 2024
    Article
  6. Article
  7. Article
  8. Early Days of Two-Dimensional Ion Cyclotron Resonance.Molecules (Basel, Switzerland) · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Phase relationships in two-dimensional mass spectrometry.Journal of the American Society for Mass Spectrometry · 2019
    Article
  13. Review
  14. Article
  15. Bottom-Up Two-Dimensional Electron-Capture Dissociation Mass Spectrometry of Calmodulin.Journal of the American Society for Mass Spectrometry · 2018
    Article
  16. Article
  17. 2D FT-ICR MS of Calmodulin: A Top-Down and Bottom-Up Approach.Journal of the American Society for Mass Spectrometry · 2016
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Maria A van AgthovenDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Mark P BarrowDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Lionel ChironNMRTEC, Bld. Sébastien Brandt, Bioparc - Bat. B, 67400, Illkirch-Graffenstaden, France.
Marie-Aude CoutoulyNMRTEC, Bld. Sébastien Brandt, Bioparc - Bat. B, 67400, Illkirch-Graffenstaden, France.
David KilgourSchool of Pharmacy, University of Maryland, Baltimore, MD, 21201, USA.
Christopher A WoottonDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Juan WeiDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Andrew SoulbyDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Marc-André DelsucNMRTEC, Bld. Sébastien Brandt, Bioparc - Bat. B, 67400, Illkirch-Graffenstaden, France.
Christian RolandoMiniaturisation pour la Synthèse, l'Analyse & la Protéomique (MSAP), USR CNRS 3290, and Protéomique, Modifications Post-traductionnelles et Glycobiologie, IFR 147 and Institut Eugène-Michel Chevreul, FR CNRS 2638, Université de Lille 1 Sciences et Technologies, 59655, Villeneuve d'Ascq Cedex, France.
Peter B O'ConnorDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. p.oconnor@warwick.ac.uk.
University of Warwick · GBInstitut de génétique et de biologie moléculaire et cellulaire · FRMiniaturisation pour la Synthèse, l'Analyse et la Protéomique · FRUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two-dimensional Fourier transform ion cyclotron resonance mass spectrometry is a data-independent analytical method that records the fragmentation patterns of all the compounds in a sample. This study shows the implementation of atmospheric pressure photoionization with two-dimensional (2D) Fourier transform ion cyclotron resonance mass spectrometry. In the resulting 2D mass spectrum, the fragmentation patterns of the radical and protonated species from cholesterol are differentiated. This study shows the use of fragment ion lines, precursor ion lines, and neutral loss lines in the 2D mass spectrum to determine fragmentation mechanisms of known compounds and to gain information on unknown ion species in the spectrum. In concert with high resolution mass spectrometry, 2D Fourier transform ion cyclotron resonance mass spectrometry can be a useful tool for the structural analysis of small molecules. Graphical Abstract ᅟ.

Indexed as

Atmospheric PressureCholesterolCyclotronsEquipment DesignFourier AnalysisIonsMass SpectrometryPhotochemical ProcessesCholesterolIonsAPPIAtmospheric pressure photoionizationCholesterolFourier transform ion cyclotron resonance mass spectrometryFT-ICR MSInfrared multiphoton dissociationIRMPDTwo-dimensional

Identifiers

PMID26184984
OpenAlexW1231945058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.