Evidence map›Paper›PMID 26184894›Full record

ReviewNeurobiology of disease2016

Cellular and molecular introduction to brain development.

Xiangning Jiang, Jeannette Nardelli

Abstract readReview
In one paragraph

Review in Neurobiology of disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed.

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  20. Modelling human brain development and disease with organoids.Nature reviews. Molecular cell biology · 2025
    Review

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xiangning JiangDepartment of Pediatrics, University of California, San Francisco, CA 94158, USA.
Jeannette NardelliInserm, U1141, Paris 75019, France; Université Paris Diderot, Sorbonne Paris Cité, UMRS 1141, Paris 75019, France. Electronic address: jeannette.nardelli@inserm.fr.

Funding

Phospho-regulation of NMDA receptors in neonatal brain hypoxia-ischemiaR01NS084057 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JIANG, XIANGNING · 2014 to 2018
$1.7M
NINDS NIH HHS R01 NS084057
6 · The paper itself

Abstract

Advances in the study of brain development over the last decades, especially recent findings regarding the evolutionary expansion of the human neocortex, and large-scale analyses of the proteome/transcriptome in the human brain, have offered novel insights into the molecular mechanisms guiding neural maturation, and the pathophysiology of multiple forms of neurological disorders. As a preamble to reviews of this issue, we provide an overview of the cellular, molecular and genetic bases of brain development with an emphasis on the major mechanisms associated with landmarks of normal neural development in the embryonic stage and early postnatal life, including neural stem/progenitor cell proliferation, cortical neuronal migration, evolution and folding of the cerebral cortex, synaptogenesis and neural circuit development, gliogenesis and myelination. We will only briefly depict developmental disorders that result from perturbations of these cellular or molecular mechanisms, and the most common perinatal brain injuries that could disturb normal brain development.

Indexed as

AnimalsBrainHumansNeurodevelopmental DisordersCerebral cortexGliogenesisNeurodevelopmentNeurodevelopmental disordersNeuronal maturationProgenitor cellSynaptogenesis

Identifiers

PMID26184894
PMCPMC4720585

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.