ArticleAutism research : official journal of the International Society for Autism Research2016
Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder.
Article in Autism research : official journal of the International Society for Autism Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Cortical thickness abnormalities in autism spectrum disorder.European child & adolescent psychiatry · 2024Pooled it
- The early life growth of head circumference, weight, and height in infants with autism spectrum disorders: a systematic review.BMC pediatrics · 2023Pooled it
- Brain Cortical Volume and Thickness Abnormalities in Autism Spectrum Disorder Aged 2-4 Years: a Structural MRI Comparative Study.Journal of autism and developmental disorders · 2026Article
- Transdiagnostic monoamine-based subtyping for attention-deficit/hyperactivity disorder and autism spectrum disorder via unsupervised machine learning.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Fetal MRI reveals altered prenatal cortical surface area in fetuses later diagnosed with autism spectrum disorder.bioRxiv : the preprint server for biology · 2026Article
- Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder.Molecular autism · 2025Article
- Mechanics of the Spatiotemporal Evolution of Sulcal Pits in the Folding Brain.Human brain mapping · 2025Article
- Subgrouping autism and ADHD based on structural MRI population modelling centiles.Molecular autism · 2025Article
- mAutism research : official journal of the International Society for Autism Research · 2025Article
- Enlarged perivascular spaces under the dorso-lateral prefrontal cortex and severity of autism.Scientific reports · 2025Observational
- Mechanisms of brain overgrowth in autism spectrum disorder with macrocephaly.Frontiers in neuroscience · 2025Review
- Autism Spectrum Disorder: Brain Areas Involved, Neurobiological Mechanisms, Diagnoses and Therapies.International journal of molecular sciences · 2024Review
- Brain-charting autism and attention deficit hyperactivity disorder reveals distinct and overlapping neurobiology.medRxiv : the preprint server for health sciences · 2023Article
- Application of Multimodal MRI in the Early Diagnosis of Autism Spectrum Disorders: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure.Translational psychiatry · 2023Article
- APPlications of amyloid-β precursor protein metabolites in macrocephaly and autism spectrum disorder.Frontiers in molecular neuroscience · 2023Review
- Assessing cortical features in early stage ASD children.Frontiers in psychiatry · 2023Article
- Why do children with autism spectrum disorder have abnormal visual perception?Frontiers in psychiatry · 2023Article
- Developmental abnormalities of structural covariance networks of cortical thickness and surface area in autistic infants within the first 2 years.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The Autism Phenome Project is the largest, single site, longitudinal magnetic resonance imaging (MRI) study of young children with autism spectrum disorder (ASD). Previous analyses from this cohort have shown that the children with autism have a total brain volume at time 1 (∼3 years of age) that is 6% larger than typically developing (TD) children. This finding is driven primarily by 15% of the boys with ASD that have disproportionate megalencephaly (ASD-DM) or brain size that is 1.5 standard deviations above what would be expected for the child's height. In the current study, cerebral cortical grey matter volume, thickness, and surface area were assayed from MRI scans of 112, 3-year-old boys with ASD and 50 age-matched TD boys. The boys with ASD-DM (n = 17) were analyzed separately from the boys with normal brain size (ASD-N, n = 95). Previous studies of cortical thickness and surface area for ASD children in this age range have come to diametrically different conclusions concerning the significance of cortical thickness vs. surface area. Current analyses indicate that cortical thickness was comparable across the ASD and TD groups. However, surface area was significantly greater in the ASD group compared to the TD group. This result was driven largely by the children with ASD-DM. Even in the ASD-DM group, not all cortical regions demonstrated increased surface area. These results provide strong evidence that the early cortical overgrowth associated with ASD is due primarily to increased surface area and not to increased cortical thickness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.