Evidence map›Paper›PMID 26184695›Full record

ArticleAtherosclerosis2015

Carotid atherosclerosis and cardiovascular health metrics in old subjects from the AGES-Reykjavik study.

Ran Sturlaugsdottir, Thor Aspelund, Gudlaug Bjornsdottir, Sigurdur Sigurdsson, Gudny Eiriksdottir, Cindy Mari Imai, Melissa Garcia, Lenore J Launer, Tamara B Harris, Vilmundur Gudnason

Abstract read
In one paragraph

Article in Atherosclerosis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Association of change in cardiovascular risk factors with incident dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ran SturlaugsdottirIcelandic Heart Association, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland.
Thor AspelundIcelandic Heart Association, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland.
Gudlaug BjornsdottirIcelandic Heart Association, Kopavogur, Iceland.
Sigurdur SigurdssonIcelandic Heart Association, Kopavogur, Iceland.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Cindy Mari ImaiIcelandic Heart Association, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland.
Melissa GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD, USA.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD, USA.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland. Electronic address: v.gudnason@hjarta.is.

Funding

CLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective studyZIAAG007380 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2009 to 2025
$6.1M
Age, Gene/Environment Susceptibility StudyZ01AG007380 · NIA · NATIONAL INSTITUTE ON AGING · PI HARRIS, TAMARA B. · 2006 to 2008
$1.3M
AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-26012100N01AG012100 · NIA · ICELANDIC HEART ASSOCIATION · 2002 to 2004
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Intramural NIH HHS Z01 AG007380NIA NIH HHS N01 AG012100NIA NIH HHS N01-AG-1-2100
6 · The paper itself

Abstract

backgroundIdeal cardiovascular (CV) health by simultaneous presence of 7 ideal health metrics (blood pressure, cholesterol, glucose, smoking, BMI, physical activity and diet) has been defined by the American Heart Association. In the current study we investigated the association of a CV health score (range 0-14), on the extent and progression of carotid atherosclerosis, assessed as carotid intima-media thickness (cIMT) and total plaque area (TPA) by ultrasound at 5 years interval. METHODS AND

resultsA total of 219 participants (age 75.6 ± 5.1) from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik study were studied. Men with poor (low) CV health score had greater TPA than those with more optimal (high) score (61.5 (SD: 32.3), 44.4 (24.2) and 37.7 (23.2) mm(2) for those with CV health score ≤6, 7-9 and ≥10 respectively, p < 0.05). In linear analysis for men, log TPA was 0.088 mm(2) (SE: 0.040 p < 0.05) smaller for each additional point in the CV health score. CV health score was not associated with TPA in women, or cIMT in either sex. TPA increased in both sexes between visits. However, CV health score did not predict carotid atherosclerosis progression.

conclusionsCV health score is associated with TPA in older men but not in women. Men with poor CV health score at the baseline visit had more extensive carotid atherosclerosis than those with better CV health score, although it did not predict the progression of carotid atherosclerosis.

Indexed as

Carotid Intima-Media ThicknessAgedAged, 80 and overCardiovascular DiseasesCarotid StenosisComorbidityCoronary DiseaseDiabetes MellitusDietDisease ProgressionFemaleFollow-Up StudiesHealth StatusHumansHyperlipidemiasHypertensionCardiovascular health scoreCarotid arteriesImaging

Identifiers

PMID26184695
PMCPMC4546903

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.