Evidence map›Paper›PMID 26184416›Full record

ArticleEndocrine2016

Improvement of anthropometric and metabolic parameters, and quality of life following treatment with dual-release hydrocortisone in patients with Addison's disease.

Roberta Giordano, Federica Guaraldi, Elisa Marinazzo, Federica Fumarola, Alessia Rampino, Rita Berardelli, Ioannis Karamouzis, Manuela Lucchiari, Tilde Manetta, Giulio Mengozzi and 2 more

Abstract read
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In one paragraph

Article in Endocrine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
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  14. Adrenocortical stem cells in health and disease.Nature reviews. Endocrinology · 2025
    Review
  15. Extended-release Hydrocortisone Formulations-Is There a Clinically Meaningful Benefit?The Journal of clinical endocrinology and metabolism · 2025
    Review
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Roberta GiordanoDepartment of Clinical and Biological Sciences, University of Turin, 10126, Turin, Italy. roberta.giordano@unito.it.
Federica GuaraldiDivision of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.
Elisa MarinazzoDivision of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.
Federica FumarolaDivision of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.
Alessia RampinoDepartment of Clinical and Biological Sciences, University of Turin, 10126, Turin, Italy.
Rita BerardelliDivision of Oncological Endocrinology, Department of Medical Sciences, University of Turin, 10126, Turin, Italy.
Ioannis KaramouzisDivision of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.
Manuela LucchiariClinical Biochemistry Laboratory, "Città della Salute e della Scienza di Torino" University Hospital, 10126, Turin, Italy.
Tilde ManettaClinical Biochemistry Laboratory, "Città della Salute e della Scienza di Torino" University Hospital, 10126, Turin, Italy.
Giulio MengozziClinical Biochemistry Laboratory, "Città della Salute e della Scienza di Torino" University Hospital, 10126, Turin, Italy.
Emanuela ArvatDivision of Oncological Endocrinology, Department of Medical Sciences, University of Turin, 10126, Turin, Italy.
Ezio GhigoDivision of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with Addison's disease (AD), a dual-release preparation of hydrocortisone (Plenadren, PLEN) has been demonstrated to maintain cortisol levels in a more physiological range than conventional glucocorticoid therapy, and to exert positive effects. This study aimed to assess variations of anthropometric, metabolic, and hormonal parameters in patients with AD after switching from conventional hydrocortisone (HC) treatment to PLEN. In nineteen AD patients (15 F and 4 M, age 27-65 years) treated with HC 20 mg/day thrice daily, body weight, BMI, waist circumference, fasting glucose, HbA1c, serum lipids, plasma renin activity, electrolytes, and blood pressure were evaluated at baseline, and 1, 3, 6, and 12 months after switching from HC to PLEN. At baseline, and after 1 and 12 months of PLEN, blood ACTH and cortisol (at 0800 h at fasting, and 30, 60, 90, 120, and 240 min after drug ingestion), and health-related quality of life (HRQoL), using 30-AddiQoL questionnaire, were evaluated. During PLEN, waist and serum lipid progressively decreased. After 12 months of PLEN, a significant difference was observed in waist circumference (P = 0.007), HbA1c (P = 0.002), total and LDL-cholesterol levels (P < 0.05). ACTH levels at 240 min and the area under the curve (AUC) were lower (P < 0.05) during PLEN than HC, while cortisol peaks and AUC were similar. 30-AddiQoL total score also improved (P = 0.04) during PLEN. In AD patients, PLEN reduces central adiposity, and improves glucose and metabolism parameters and HRQoL.

Indexed as

Hormone Replacement TherapyQuality of LifeAddison DiseaseAdultAgedBlood PressureBody Mass IndexDelayed-Action PreparationsFemaleGlucocorticoidsHumansHydrocortisoneLipidsMaleMiddle AgedTreatment OutcomeDelayed-Action PreparationsGlucocorticoidsHydrocortisoneLipidsAddison’s diseaseDual-release hydrocortisoneMetabolismQoL

Identifiers

PMID26184416

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.