Evidence map›Paper›PMID 26184327›Full record

ReviewJournal of functional biomaterials2015

Advances in Skin Substitutes-Potential of Tissue Engineered Skin for Facilitating Anti-Fibrotic Healing.

Mathew Varkey, Jie Ding, Edward E Tredget

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of functional biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 177 citations in OpenAlex.

  1. Review
  2. Skin substitutes: from conventional to 3D bioprinting.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. [Heterogeneous acellular dermal matrix for wound repair after endoscopic Type-Ⅴa cordectomy].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Review
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  14. Review
  15. Scars.Nature reviews. Disease primers · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mathew VarkeyWound Healing Research Group, Division of Plastic and Reconstructive Surgery, University of Alberta, 2D3.81 WMSHC, 8440-112 Street, Edmonton, AB T6G 2B7, Canada. mvarkey@ualberta.ca.
Jie DingWound Healing Research Group, Division of Plastic and Reconstructive Surgery, University of Alberta, 2D3.81 WMSHC, 8440-112 Street, Edmonton, AB T6G 2B7, Canada. jied@ualberta.ca.
Edward E TredgetWound Healing Research Group, Division of Plastic and Reconstructive Surgery, University of Alberta, 2D3.81 WMSHC, 8440-112 Street, Edmonton, AB T6G 2B7, Canada. etredget@ualberta.ca.
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin protects the body from exogenous substances and functions as a barrier to fluid loss and trauma. The skin comprises of epidermal, dermal and hypodermal layers, which mainly contain keratinocytes, fibroblasts and adipocytes, respectively, typically embedded on extracellular matrix made up of glycosaminoglycans and fibrous proteins. When the integrity of skin is compromised due to injury as in burns the coverage of skin has to be restored to facilitate repair and regeneration. Skin substitutes are preferred for wound coverage when the loss of skin is extensive especially in the case of second or third degree burns. Different kinds of skin substitutes with different features are commercially available; they can be classified into acellular skin substitutes, those with cultured epidermal cells and no dermal components, those with only dermal components, and tissue engineered substitutes that contain both epidermal and dermal components. Typically, adult wounds heal by fibrosis. Most organs are affected by fibrosis, with chronic fibrotic diseases estimated to be a leading cause of morbidity and mortality. In the skin, fibroproliferative disorders such as hypertrophic scars and keloid formation cause cosmetic and functional problems. Dermal fibroblasts are understood to be heterogeneous; this may have implications on post-burn wound healing since studies have shown that superficial and deep dermal fibroblasts are anti-fibrotic and pro-fibrotic, respectively. Selective use of superficial dermal fibroblasts rather than the conventional heterogeneous dermal fibroblasts may prove beneficial for post-burn wound healing.

Indexed as

fibrosisskin substitutestissue engineeringwound healing

Identifiers

PMID26184327
PMCPMC4598670
OpenAlexW1556407989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.