Evidence map›Paper›PMID 26184319›Full record

ReviewGenes2015

One, Two, Three: Polycomb Proteins Hit All Dimensions of Gene Regulation.

Stefania Del Prete, Pawel Mikulski, Daniel Schubert, Valérie Gaudin

Open access · goldAbstract readReview
In one paragraph

Review in Genes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Stefania Del PreteINRA, UMR1318-AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), INRA-Centre de Versailles-Grignon, Route de St-Cyr, Versailles Cedex F-78026, France. stefania.del-prete@versailles.inra.fr.
Pawel MikulskiInstitute for Genetics, HHU Duesseldorf, Universitätsstraße 1, Duesseldorf D-40225, Germany. Pawel.Mikulski@uni-duesseldorf.de.
Daniel SchubertInstitute for Genetics, HHU Duesseldorf, Universitätsstraße 1, Duesseldorf D-40225, Germany. Dan.Schubert@fu-berlin.de.
Valérie GaudinINRA, UMR1318-AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), INRA-Centre de Versailles-Grignon, Route de St-Cyr, Versailles Cedex F-78026, France. valerie.gaudin@versailles.inra.fr.
Heinrich Heine University Düsseldorf · DEInstitut Jean-Pierre Bourgin · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycomb group (PcG) proteins contribute to the formation and maintenance of a specific repressive chromatin state that prevents the expression of genes in a particular space and time. Polycomb repressive complexes (PRCs) consist of several PcG proteins with specific regulatory or catalytic properties. PRCs are recruited to thousands of target genes, and various recruitment factors, including DNA-binding proteins and non-coding RNAs, are involved in the targeting. PcG proteins contribute to a multitude of biological processes by altering chromatin features at different scales. PcG proteins mediate both biochemical modifications of histone tails and biophysical modifications (e.g., chromatin fiber compaction and three-dimensional (3D) chromatin conformation). Here, we review the role of PcG proteins in nuclear architecture, describing their impact on the structure of the chromatin fiber, on chromatin interactions, and on the spatial organization of the genome in nuclei. Although little is known about the role of plant PcG proteins in nuclear organization, much is known in the animal field, and we highlight similarities and differences in the roles of PcG proteins in 3D gene regulation in plants and animals.

Indexed as

Arabidopsis thalianachromatinchromatin loopslaminsPolycombPolycomb bodiesthree-dimensional nuclear architecturetopologically associating domain (TAD)

Identifiers

PMID26184319
PMCPMC4584315
OpenAlexW1809321693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.