Difference in Pro-Inflammatory Cytokine Responses Induced in THP1 Cells by Particulate Matter Collected on Days with and without ASIAN Dust Storms.

Masanari Watanabe, Jun Kurai, Hiroyuki Sano, Akira Yamasaki, Eiji Shimizu

Abstract read

In one paragraph

Article in International journal of environmental research and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Masanari WatanabeDepartment of Respiratory Medicine and Rheumatology, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago 683-8504, Japan. watanabm@grape.med.tottori-u.ac.jp.

Jun KuraiDepartment of Respiratory Medicine and Rheumatology, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago 683-8504, Japan. junkurajun@gmail.com.

Hiroyuki SanoDepartment of Respiratory Medicine and Allergology, Kinki University Faculty of Medicine, 377-2 Ohnohigashi, Osakasayama 589-0014, Japan. hsano@med.kindai.ac.jp.

Akira YamasakiDepartment of Respiratory Medicine and Rheumatology, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago 683-8504, Japan. yamasaki@med.tottori-u.ac.jp.

Eiji ShimizuDepartment of Respiratory Medicine and Rheumatology, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago 683-8504, Japan. eiji@med.tottori-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The associations between particulate matter from Asian dust storms (ADS) and health disorders differ among studies, and the underlying mechanisms remain unclear. In this study, ADS and non-ADS particles were tested for their potential to induce pro-inflammatory cytokines associated with adverse respiratory effects. Particulate matter was collected in Japan during four periods in 2013 (2 × ADS periods; 2 × non-ADS). THP1 cells were exposed to this particulate matter, and the levels of various interleukins (ILs), and tumor necrosis factor (TNF)-α were measured. Levels of IL-2 increased significantly following exposure to all particulate matter samples (compared to levels in a solvent control). Increased levels of IL-10 and TNF-α were also observed following exposure to particles collected during three (one ADS and two non-ADS) and two (one ADS and one non-ADS) collection periods, respectively. Thus, the effects of particulate matter on cytokine responses differed according to collection period, and the effects of ADS particles differed for each ADS event. Additionally, the levels of pro-inflammatory cytokines induced by ADS particles were not always higher than those induced by non-ADS particles.

Indexed as

CytokinesDustHumansInterleukin-10InterleukinsJapanMonocytesParticulate MatterTumor Necrosis Factor-alphaCytokinesDustIL10 protein, humanInterleukin-10InterleukinsParticulate MatterTNF protein, humanTumor Necrosis Factor-alphaAsian dust stormcytokineparticulate matterTHP1

Identifiers

PMID26184251

DOI10.3390/ijerph120707725

PMCPMC4515687

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.