ArticleMolecules (Basel, Switzerland)2015
Anti-Protozoal Activities of Cembrane-Type Diterpenes from Vietnamese Soft Corals.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Pooled it
- Pooled it
- Diterpenoids of Marine Organisms: Isolation, Structures, and Bioactivities.Marine drugs · 2025Review
- Marine organisms as potential sources of natural products for the prevention and treatment of malaria.RSC advances · 2023Review
- The application and sustainable development of coral in traditional medicine and its chemical composition, pharmacology, toxicology, and clinical research.Frontiers in pharmacology · 2023Review
- Cnidarians as a potential source of antiparasitic drugs.Parasitology research · 2022Review
- Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria.Marine drugs · 2020Review
- Article
- A Brief Review on New Naturally Occurring Cembranoid Diterpene Derivatives from the Soft Corals of the GeneraMolecules (Basel, Switzerland) · 2019Review
- Current understanding and biotechnological application of the bacterial diterpene synthase CotB2.Beilstein journal of organic chemistry · 2019Review
- A High-Content Screening Assay for the Discovery of Novel Proteasome Inhibitors from Formosan Soft Corals.Marine drugs · 2018Article
- Sesquiterpene Lactones from Vernonia cinerascens Sch. Bip. and Their in Vitro Antitrypanosomal Activity.Molecules (Basel, Switzerland) · 2018Article
- Hemolytic, anticancer and antigiardial activity ofThe journal of venomous animals and toxins including tropical diseases · 2018Article
- New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sarcophyton ehrenbergi.Molecules (Basel, Switzerland) · 2016Article
- Phenolic Constituents of Medicinal Plants with Activity against Trypanosoma brucei.Molecules (Basel, Switzerland) · 2016Article
- In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase.Molecules (Basel, Switzerland) · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on our previous finding that certain cembranoid diterpenes possess selective toxicity against protozoan pathogens of tropical diseases such as Trypanosoma and Plasmodium, we have subjected a series of 34 cembranes isolated from soft corals living in the Vietnamese sea to an in vitro screening for anti-protozoal activity against Trypanosoma brucei rhodesiense (Tbr), T. cruzi (Tc), Leishmania donovani (Ld), and Plasmodium falciparum (Pf). Twelve of the tested compounds displayed significant activity against at least one of the parasites. Specifically, 7S,8S-epoxy-1,3,11-cembratriene-16-oic methyl ester (1), (1R,4R,2E,7E,11E)-cembra-2,7,11-trien-4-ol (2), crassumol D (12), crassumol E (13), and (1S,2E,4S,6E,8S,11S)-2,6,12(20)-cembrantriene-4,8,11-triol (16) from Lobophytum crassum, L. laevigatum, and Sinularia maxima showed the highest level of inhibitory activity against T. b. rhodesiense, with IC50 values of about 1 µM or less. Lobocrasol A (6) and lobocrasol C (8) from L. crassum and L. laevigatum exhibited particularly significant inhibitory effects on L. donovani with IC50 values < 0.2 µM. The best antiplasmodial effect was exerted by laevigatol A (10), with an IC50 value of about 3.0 µM. The cytotoxicity of the active compounds on L6 rat skeletal myoblast cell was also assessed and found to be insignificant in all cases. This is the first report on anti-protozoal activity of these compounds, and points out the potential of the soft corals in discovery of new anti-protozoal lead compounds.
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