ArticleClinical journal of gastroenterology2014
Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule.
Article in Clinical journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Primary hepatic neuroendocrine tumor with a suspicious pulmonary nodule: A case report and literature review.World journal of clinical oncology · 2025Article
- Review
- Primary giant hepatic neuroendocrine neoplasms in a young adult: case report and literature review.Frontiers in oncology · 2025Article
- Collision Tumor of Gallbladder Carcinosarcoma and Intrahepatic Cholangiocarcinoma: A Rare Case Report.Surgical case reports · 2025Article
- Primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy: a case report.Surgical case reports · 2021Article
- A case of primary hepatic mixed neuroendocrine-non-neuroendocrine tumor (MiNEN) associated with gallbladder carcinosarcoma.Clinical journal of gastroenterology · 2020Article
- Primary hepatic neuroendocrine carcinoma coexisting with distal cholangiocarcinoma: A case report and review of the literature.Medicine · 2020Review
- Long term recurrence in primary liver neuroendocrine tumor: Report of a single case and review of literature.Annals of hepato-biliary-pancreatic surgery · 2018Article
- Combination therapies for primary hepatic neuroendocrine carcinoma: a case report.Surgical case reports · 2017Article
- Mixed Neuroendocrine-Nonneuroendocrine Neoplasms (MiNENs): Unifying the Concept of a Heterogeneous Group of Neoplasms.Endocrine pathology · 2016Review
- Histological features of mixed neuroendocrine carcinoma and hepatocellular carcinoma in the liver: a case report and literature review.Clinical journal of gastroenterology · 2016Review
- Primary Hepatic Neuroendocrine Carcinoma with Metastasis to the Mesentery: A Case Report.Case reports in oncologyArticle
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary neuroendocrine carcinomas (NECs) in the liver are very rare; however, several reports have described cases of a primary hepatic NEC combined with a hepatocellular carcinoma (HCC). We present the first report of a primary hepatic NEC with a cholangiocellular carcinoma (CCC) component in one nodule in a patient with a metachronous liver HCC. A 73-year old man who had received partial hepatectomy surgery because of a primary HCC and a primary CCC two years prior was diagnosed with a primary hepatic NEC after surgical treatment. Histological analysis of the resected tumor revealed that the tumor consisted of a predominant NEC area with a partial CCC component in one nodule and that the NEC cells were negative for markers of pancreatic NEC. Neoplastic cells in both the NEC and CCC component focally expressed CD44, a representative marker for cancer-initiating cells, and the CD44-positive cells in the NEC component were seen in the vicinity of those in the CCC component of one nodule. This case report provides suggestive information for the origin of primary hepatic NECs.
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