Evidence map›Paper›PMID 26183963›Full record

ArticleAnnals of biomedical engineering2016

Fluid-Structure Interaction Analysis of Papillary Muscle Forces Using a Comprehensive Mitral Valve Model with 3D Chordal Structure.

Milan Toma, Morten Ø Jensen, Daniel R Einstein, Ajit P Yoganathan, Richard P Cochran, Karyn S Kunzelman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
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  6. Review
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  9. Article
  10. Clinical Impact of Computational Heart Valve Models.Materials (Basel, Switzerland) · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Automatic extraction of the mitral valve chordae geometry for biomechanical simulation.International journal of computer assisted radiology and surgery · 2021
    Article
  15. Review
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Milan TomaDepartment of Biomedical Engineering, Georgia Institute of Technology, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.
Morten Ø JensenDepartment of Biomedical Engineering, Georgia Institute of Technology, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.
Daniel R EinsteinComputational Biology & Bioinformatics, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
Ajit P YoganathanDepartment of Biomedical Engineering, Georgia Institute of Technology, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.
Richard P CochranDepartment of Mechanical Engineering, University of Maine, 219 Boardman Hall, Orono, ME, 04469-5711, USA.
Karyn S KunzelmanDepartment of Mechanical Engineering, University of Maine, 219 Boardman Hall, Orono, ME, 04469-5711, USA. karyn.cochran@maine.edu.
Georgia Institute of Technology · USUniversity of Maine · USPacific Northwest National Laboratory · US

Funding

Percutaneous Mitral Valve Repair: A Validated Fluid-Structure Interaction ModelR01HL092926 · NHLBI · UNIVERSITY OF MAINE ORONO · PI KUNZELMAN, KARYN S · 2009 to 2013
$2.9M
NHLBI NIH HHS R01 HL092926NHLBI NIH HHS R01-HL092926
6 · The paper itself

Abstract

Numerical models of native heart valves are being used to study valve biomechanics to aid design and development of repair procedures and replacement devices. These models have evolved from simple two-dimensional approximations to complex three-dimensional, fully coupled fluid-structure interaction (FSI) systems. Such simulations are useful for predicting the mechanical and hemodynamic loading on implanted valve devices. A current challenge for improving the accuracy of these predictions is choosing and implementing modeling boundary conditions. In order to address this challenge, we are utilizing an advanced in vitro system to validate FSI conditions for the mitral valve system. Explanted ovine mitral valves were mounted in an in vitro setup, and structural data for the mitral valve was acquired with [Formula: see text]CT. Experimental data from the in vitro ovine mitral valve system were used to validate the computational model. As the valve closes, the hemodynamic data, high speed leaflet dynamics, and force vectors from the in vitro system were compared to the results of the FSI simulation computational model. The total force of 2.6 N per papillary muscle is matched by the computational model. In vitro and in vivo force measurements enable validating and adjusting material parameters to improve the accuracy of computational models. The simulations can then be used to answer questions that are otherwise not possible to investigate experimentally. This work is important to maximize the validity of computational models of not just the mitral valve, but any biomechanical aspect using computational simulation in designing medical devices.

Indexed as

Models, CardiovascularAnimalsChordae TendineaeIn Vitro TechniquesMitral ValvePapillary MusclesSheepX-Ray MicrotomographyChordal structureComprehensive computational modelFluid–structure interactionForcesMitral valvePapillary muscle

Identifiers

PMID26183963
PMCPMC4715994
OpenAlexW2251076411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.