ArticleNature communications2015
Insect glycerol transporters evolved by functional co-option and gene replacement.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 84 citations in OpenAlex.
- Surviving Alpine Winters Without Dehydration: Physiological and Transcriptomic Insights into the Freeze Avoidance ofInsects · 2026Article
- Chromosomal Replication, Translocation and Recombination as Putative Events in the Diversification of VertebrateInternational journal of molecular sciences · 2026Article
- Independent divergences of the aquaporins across different genera highlight the distinct adaptation mechanisms within Mytilida.BMC genomics · 2025Article
- Co-opted and canonical glycerol channels play a major role during anhydrobiosis of an extremophile crustacean.BMC biology · 2025Article
- Exploring Aquaporins in Human Studies: Mechanisms and Therapeutic Potential in Critical Illness.Life (Basel, Switzerland) · 2024Review
- Permeability and Toxicity of Cryoprotective Agents in Silkworm Embryos: Impact on Cryopreservation.International journal of molecular sciences · 2024Article
- Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes.Genome biology and evolution · 2024Article
- Protein localization of aquaporins in the adult female disease vector mosquito,Frontiers in insect science · 2024Article
- Article
- Identification and characterization of cold-responsive aquaporins from the larvae of a crambid pestPeerJ · 2023Article
- Evolutionary Overview of Aquaporin Superfamily.Advances in experimental medicine and biology · 2023Article
- Fluid transport in the brain.Physiological reviews · 2022Review
- Diversification of the aquaporin family in geographical isolated oyster species promote the adaptability to dynamic environments.BMC genomics · 2022Article
- The Genome ofGenes · 2022Article
- Article
- Article
- Lineage-level divergence of copepod glycerol transporters and the emergence of isoform-specific trafficking regulation.Communications biology · 2021Article
- Article
- Molecular mechanisms underlying milk production and viviparity in the cockroach, Diploptera punctata.Insect biochemistry and molecular biology · 2020Article
- Coordination of host and symbiont gene expression reveals a metabolic tug-of-war between aphids andProceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transmembrane glycerol transport is typically facilitated by aquaglyceroporins in Prokaryota and Eukaryota. In holometabolan insects however, aquaglyceroporins are absent, yet several species possess polyol permeable aquaporins. It thus remains unknown how glycerol transport evolved in the Holometabola. By combining phylogenetic and functional studies, here we show that a more efficient form of glycerol transporter related to the water-selective channel AQP4 specifically evolved and multiplied in the insect lineage, resulting in the replacement of the ancestral branch of aquaglyceroporins in holometabolan insects. To recapitulate this evolutionary process, we generate specific mutants in distantly related insect aquaporins and human AQP4 and show that a single mutation in the selectivity filter converted a water-selective channel into a glycerol transporter at the root of the crown clade of hexapod insects. Integration of phanerozoic climate models suggests that these events were associated with the emergence of complete metamorphosis and the unparalleled radiation of insects.
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